Disentangling glial diversity in peripheral nerves at single-nuclei resolution.
Journal
Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
13
05
2021
accepted:
14
12
2021
pubmed:
5
2
2022
medline:
27
4
2022
entrez:
4
2
2022
Statut:
ppublish
Résumé
The peripheral nerve contains diverse cell types that support its proper function and maintenance. In this study, we analyzed multiple peripheral nerves using single-nuclei RNA sequencing, which allowed us to circumvent difficulties encountered in analyzing cells with complex morphologies via conventional single-cell methods. The resultant mouse peripheral nerve cell atlas highlights a diversity of cell types, including multiple subtypes of Schwann cells (SCs), immune cells and stromal cells. We identified a distinct myelinating SC subtype that expresses Cldn14, Adamtsl1 and Pmp2 and preferentially ensheathes motor axons. The number of these motor-associated Pmp2
Identifiants
pubmed: 35115729
doi: 10.1038/s41593-021-01005-1
pii: 10.1038/s41593-021-01005-1
pmc: PMC9060899
mid: NIHMS1791514
doi:
Substances chimiques
Superoxide Dismutase
EC 1.15.1.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
238-251Subventions
Organisme : NIAID NIH HHS
ID : R37 AI049653
Pays : United States
Organisme : NIMH NIH HHS
ID : RF1 MH117070
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS078398
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK119147
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM123203
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS105645
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG013730
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG013730
Pays : United States
Organisme : NINDS NIH HHS
ID : K08 NS107621
Pays : United States
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.
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