Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines.
Journal
Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
20
05
2021
accepted:
16
12
2021
pubmed:
5
2
2022
medline:
20
4
2022
entrez:
4
2
2022
Statut:
ppublish
Résumé
Answer ALS is a biological and clinical resource of patient-derived, induced pluripotent stem (iPS) cell lines, multi-omic data derived from iPS neurons and longitudinal clinical and smartphone data from over 1,000 patients with ALS. This resource provides population-level biological and clinical data that may be employed to identify clinical-molecular-biochemical subtypes of amyotrophic lateral sclerosis (ALS). A unique smartphone-based system was employed to collect deep clinical data, including fine motor activity, speech, breathing and linguistics/cognition. The iPS spinal neurons were blood derived from each patient and these cells underwent multi-omic analytics including whole-genome sequencing, RNA transcriptomics, ATAC-sequencing and proteomics. The intent of these data is for the generation of integrated clinical and biological signatures using bioinformatics, statistics and computational biology to establish patterns that may lead to a better understanding of the underlying mechanisms of disease, including subgroup identification. A web portal for open-source sharing of all data was developed for widespread community-based data analytics.
Identifiants
pubmed: 35115730
doi: 10.1038/s41593-021-01006-0
pii: 10.1038/s41593-021-01006-0
pmc: PMC8825283
mid: NIHMS1765375
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
226-237Subventions
Organisme : NINDS NIH HHS
ID : R01 NS094239
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG062171
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS085207
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS122236
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM087237
Pays : United States
Organisme : NINDS NIH HHS
ID : K08 NS104273
Pays : United States
Organisme : NINDS NIH HHS
ID : U24 NS078736
Pays : United States
Organisme : NINDS NIH HHS
ID : P01 NS099114
Pays : United States
Informations de copyright
© 2022. The Author(s).
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