High-Frequency Head Impact Disrupts Hippocampal Neural Ensemble Dynamics.
brain injury–traumatic
calcium imaging
mouse model
plasticity
subconcussive head impact
Journal
Frontiers in cellular neuroscience
ISSN: 1662-5102
Titre abrégé: Front Cell Neurosci
Pays: Switzerland
ID NLM: 101477935
Informations de publication
Date de publication:
2021
2021
Historique:
received:
23
08
2021
accepted:
21
12
2021
entrez:
4
2
2022
pubmed:
5
2
2022
medline:
5
2
2022
Statut:
epublish
Résumé
We have recently shown that the cognitive impairments in a mouse model of high-frequency head impact (HFHI) are caused by chronic changes to synaptic physiology. To better understand these synaptic changes occurring after repeat head impact, we used Thy1-GcCAMP6f mice to study intracellular and intercellular calcium dynamics and neuronal ensembles in HFHI mice. We performed simultaneous calcium imaging and local field potential (LFP) recordings of the CA1 field during an early-LTP paradigm in acute hippocampal slice preparations 24 h post-impact. As previously reported, HFHI causes a decrease in early-LTP in the absence of any shift in the input-output curve. Calcium analytics revealed that HFHI hippocampal slices have similar numbers of active ROIs, however, the number of calcium transients per ROI was significantly increased in HFHI slices. Ensembles consist of coordinated activity between groups of active ROIs. We exposed the CA1 ensemble to Schaffer-collateral stimulation in an abbreviated LTP paradigm and observed novel coordinated patterns of post stimulus calcium ensemble activity. HFHI ensembles displayed qualitatively similar patterns of post-stimulus ensemble activity to shams but showed significant changes in quantitative ensemble inactivation and reactivation. Previous
Identifiants
pubmed: 35115908
doi: 10.3389/fncel.2021.763423
pmc: PMC8806157
doi:
Types de publication
Journal Article
Langues
eng
Pagination
763423Subventions
Organisme : NINDS NIH HHS
ID : F30 NS122281
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS107370
Pays : United States
Organisme : NINDS NIH HHS
ID : RF1 NS121316
Pays : United States
Organisme : NINDS NIH HHS
ID : T32 NS041218
Pays : United States
Informations de copyright
Copyright © 2022 Chapman, Sloley, Caccavano, Vicini and Burns.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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