Cdyl Deficiency Brakes Neuronal Excitability and Nociception through Promoting Kcnb1 Transcription in Peripheral Sensory Neurons.

Animals Co-Repressor Proteins / genetics Histones / genetics Hydro-Lyases / genetics Mice Nociception Sensory Receptor Cells / metabolism Shab Potassium Channels / genetics
Kv2.1 channel chromodomain Y-like epigenetic regulation novel chromodomain Y-like antagonist pain sensation

Journal

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569

Informations de publication

Date de publication:
04 2022
Historique:
revised: 28 12 2021
received: 28 09 2021
pubmed: 5 2 2022
medline: 8 4 2022
entrez: 4 2 2022
Statut: ppublish

Résumé

Epigenetic modifications are involved in the onset, development, and maintenance of pain; however, the precise epigenetic mechanism underlying pain regulation remains elusive. Here it is reported that the epigenetic factor chromodomain Y-like (CDYL) is crucial for pain processing. Selective knockout of CDYL in sensory neurons results in decreased neuronal excitability and nociception. Moreover, CDYL facilitates histone 3 lysine 27 trimethylation (H3K27me3) deposition at the Kcnb1 intron region thus silencing voltage-gated potassium channel (K

Identifiants

DOI: 10.1002/advs.202104317 PMID: 35119221 PMC: PMC8981457
pubmed: 35119221
doi: 10.1002/advs.202104317
pmc: PMC8981457
doi:

Substances chimiques

Co-Repressor Proteins 0
Histones 0
Kcnb1 protein, mouse 0
Shab Potassium Channels 0
Cdyl protein, mouse EC 4.2.1.-
Hydro-Lyases EC 4.2.1.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2104317

Subventions

Organisme : NCI NIH HHS
ID : P30 CA016086
Pays : United States
Organisme : NIDA NIH HHS
ID : R61 DA047023
Pays : United States
Organisme : NIDA NIH HHS
ID : R61DA047023-01
Pays : United States

Commentaires et corrections

Type : ErratumIn

Informations de copyright

© 2022 The Authors. Advanced Science published by Wiley-VCH GmbH.

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Auteurs

Zhao-Wei Sun (ZW)

Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100083, China.
Institute of Military Cognitive and Brain Sciences, Academy of Military Medical Sciences, Beijing, 100039, China.

Jarod M Waybright (JM)

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

Serap Beldar (S)

Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario, M5G 1L7, Canada.

Lu Chen (L)

Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100083, China.

Caroline A Foley (CA)

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

Jacqueline L Norris-Drouin (JL)

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

Tian-Jie Lyu (TJ)

Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100083, China.

Aiping Dong (A)

Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario, M5G 1L7, Canada.

Jinrong Min (J)

Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario, M5G 1L7, Canada.
Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan, Hubei, 430079, China.
Department of Physiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.

Yu-Pu Wang (YP)

Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100083, China.

Lindsey I James (LI)

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

Yun Wang (Y)

Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100083, China.
PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, 100871, China.
ORCID: 0000-0002-4357-8166

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Cdyl Deficiency Brakes Neuronal Excitability...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines de répression › Protéines corépressives › Cdyl Deficiency Brakes Neuronal Excitability...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › Cdyl Deficiency Brakes Neuronal Excitability...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Lyases › Carbon-oxygen lyases › Hydro-lyases › Cdyl Deficiency Brakes Neuronal Excitability...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Cdyl Deficiency Brakes Neuronal Excitability...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Perception › Perception de la douleur › Nociception › Cdyl Deficiency Brakes Neuronal Excitability...
questionsmedicales.fr › Cellules › Neurones › Neurones afférents › Cellules réceptrices sensorielles › Cdyl Deficiency Brakes Neuronal Excitability...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques voltage-dépendants › Canaux potassiques de la superfamille Shaker › Canaux potassiques Shab › Cdyl Deficiency Brakes Neuronal Excitability...