A glucose-based molecular rotor inhibitor of glycogen phosphorylase as a probe of cellular enzymatic function.

Animals Binding Sites Crystallography, X-Ray Enzyme Inhibitors / chemistry Glucose / analysis Glycogen Phosphorylase / antagonists & inhibitors Kinetics Molecular Probes / chemistry Oligosaccharides Rabbits

Journal

Organic & biomolecular chemistry
ISSN: 1477-0539
Titre abrégé: Org Biomol Chem
Pays: England
ID NLM: 101154995

Informations de publication

Date de publication:
23 03 2022
Historique:
pubmed: 5 2 2022
medline: 12 4 2022
entrez: 4 2 2022
Statut: epublish

Résumé

Molecular rotors belong to a family of fluorescent compounds characterized as molecular switches, where a fluorescence on/off signal signifies a change in the molecule's microenvironment. Herein, the successful synthesis and detailed study of (

Identifiants

DOI: 10.1039/d1ob02211c PMID: 35119451
pubmed: 35119451
doi: 10.1039/d1ob02211c
doi:

Substances chimiques

Enzyme Inhibitors 0
Molecular Probes 0
Oligosaccharides 0
glucopyranosyl-acarviosinyl-glucopyranose 0
Glycogen Phosphorylase EC 2.4.1.-
Glucose IY9XDZ35W2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2407-2423

Auteurs

Michail-Panagiotis Minadakis (MP)

Department of Chemistry, National and Kapodistrian University of Athens, 15771 Athens, Greece. gimisis@chem.uoa.gr.
ORCID: 0000-0002-5440-5156

Konstantinos F Mavreas (KF)

Department of Chemistry, National and Kapodistrian University of Athens, 15771 Athens, Greece. gimisis@chem.uoa.gr.
ORCID: 0000-0002-9552-2279

Dionysios D Neofytos (DD)

Institute of Chemical Biology, National Hellenic Research Foundation, 11635 Athens, Greece. echrysina@eie.gr.
ORCID: 0000-0003-0594-2163

Maria Paschou (M)

Department of Biology, National and Kapodistrian University of Athens, 15771 Athens, Greece. ppapaz@biol.uoa.gr.

Artemis Kogkaki (A)

Department of Biology, National and Kapodistrian University of Athens, 15771 Athens, Greece. ppapaz@biol.uoa.gr.

Varvara Athanasiou (V)

Department of Chemistry, National and Kapodistrian University of Athens, 15771 Athens, Greece. gimisis@chem.uoa.gr.

Michael Mamais (M)

Department of Chemistry, National and Kapodistrian University of Athens, 15771 Athens, Greece. gimisis@chem.uoa.gr.
ORCID: 0000-0002-7671-6887

Daniele Veclani (D)

Istituto ISOF, Area della Ricerca di Bologna CNR, Via P. Gobetti 101, 40129 Bologna, Italy. alessandro.venturini@isof.cnr.it.

Hermis Iatrou (H)

Department of Chemistry, National and Kapodistrian University of Athens, 15771 Athens, Greece. gimisis@chem.uoa.gr.
ORCID: 0000-0001-9358-0769

Alessandro Venturini (A)

Istituto ISOF, Area della Ricerca di Bologna CNR, Via P. Gobetti 101, 40129 Bologna, Italy. alessandro.venturini@isof.cnr.it.

Evangelia D Chrysina (ED)

Institute of Chemical Biology, National Hellenic Research Foundation, 11635 Athens, Greece. echrysina@eie.gr.
ORCID: 0000-0001-8147-9030

Panagiota Papazafiri (P)

Department of Biology, National and Kapodistrian University of Athens, 15771 Athens, Greece. ppapaz@biol.uoa.gr.
ORCID: 0000-0001-8388-4099

Thanasis Gimisis (T)

Department of Chemistry, National and Kapodistrian University of Athens, 15771 Athens, Greece. gimisis@chem.uoa.gr.
ORCID: 0000-0003-1408-2505

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › A glucose-based molecular rotor inhibitor of...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › A glucose-based molecular rotor inhibitor of...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › A glucose-based molecular rotor inhibitor of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › A glucose-based molecular rotor inhibitor of...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › A glucose-based molecular rotor inhibitor of...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Hexosyltransferases › Glucosyltransferases › Phosphorylases › Glycogen phosphorylase › A glucose-based molecular rotor inhibitor of...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › A glucose-based molecular rotor inhibitor of...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Sondes moléculaires › A glucose-based molecular rotor inhibitor of...
questionsmedicales.fr › Glucides › Polyosides › Oligosaccharides › A glucose-based molecular rotor inhibitor of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Lagomorpha › Lapins › A glucose-based molecular rotor inhibitor of...