SNARE proteins: zip codes in vesicle targeting?
membrane fusion
snare proteins
trafficking
Journal
The Biochemical journal
ISSN: 1470-8728
Titre abrégé: Biochem J
Pays: England
ID NLM: 2984726R
Informations de publication
Date de publication:
11 02 2022
11 02 2022
Historique:
received:
12
10
2021
revised:
01
12
2021
accepted:
22
12
2021
entrez:
4
2
2022
pubmed:
5
2
2022
medline:
16
2
2022
Statut:
ppublish
Résumé
Membrane traffic in eukaryotic cells is mediated by transport vesicles that bud from a precursor compartment and are transported to their destination compartment where they dock and fuse. To reach their intracellular destination, transport vesicles contain targeting signals such as Rab GTPases and polyphosphoinositides that are recognized by tethering factors in the cytoplasm and that connect the vesicles with their respective destination compartment. The final step, membrane fusion, is mediated by SNARE proteins. SNAREs are connected to targeting signals and tethering factors by multiple interactions. However, it is still debated whether SNAREs only function downstream of targeting and tethering or whether they also participate in regulating targeting specificity. Here, we review the evidence and discuss recent data supporting a role of SNARE proteins as targeting signals in vesicle traffic.
Identifiants
pubmed: 35119456
pii: 230735
doi: 10.1042/BCJ20210719
pmc: PMC8883487
doi:
Substances chimiques
SNARE Proteins
0
rab GTP-Binding Proteins
EC 3.6.5.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
273-288Informations de copyright
© 2022 The Author(s).
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