Autophagy inhibitors alleviate Japanese encephalitis virus-induced cerebral inflammation in mice.
Journal
Archives of virology
ISSN: 1432-8798
Titre abrégé: Arch Virol
Pays: Austria
ID NLM: 7506870
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
16
06
2021
accepted:
08
09
2021
pubmed:
5
2
2022
medline:
3
3
2022
entrez:
4
2
2022
Statut:
ppublish
Résumé
Japanese encephalitis (JE) is a zoonotic epidemic disease caused by Japanese encephalitis virus (JEV), and currently, no medicines are available to treat this disease. Autophagy modulators play an important role in the treatment of tumors, heart disease, and some viral diseases. The aim of this study was to investigate the effects of autophagy modulators on JEV infection and the host response in mice. The experimental mice were grouped as follows: DMEM (control), JEV, JEV+rapamycin (JEV+Rapa), JEV+wortmannin (JEV+Wort), JEV+chloroquine (JEV+CQ), Rapa, Wort, and CQ. The control group was treated with DMEM. The mice in other groups were infected with 10
Identifiants
pubmed: 35119507
doi: 10.1007/s00705-021-05283-9
pii: 10.1007/s00705-021-05283-9
pmc: PMC8814803
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
849-859Subventions
Organisme : National Key Research and Development Program of China
ID : 2016YFD0500407
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.
Références
Autophagy. 2015;11(3):503-15
pubmed: 25714412
Biomed Res Int. 2014;2014:498083
pubmed: 24779013
PLoS Negl Trop Dis. 2015 Dec 10;9(12):e0004074
pubmed: 26657648
Rev Med Virol. 2012 Mar;22(2):69-87
pubmed: 22086854
Sci Rep. 2018 May 21;8(1):7951
pubmed: 29784969
J Virol. 2012 Aug;86(16):8527-35
pubmed: 22647692
Am J Trop Med Hyg. 1999 Mar;60(3):338-42
pubmed: 10466958
Autophagy. 2014 Sep;10(9):1637-51
pubmed: 25046112
Vaccine. 2001 Aug 14;19(31):4557-65
pubmed: 11483284
Microbes Infect. 2012 Feb;14(2):159-68
pubmed: 21946213
Sci Rep. 2018 Nov 9;8(1):16595
pubmed: 30413749
Viruses. 2017 Nov 24;9(12):
pubmed: 29186766
J Biol Chem. 2010 Apr 2;285(14):10850-61
pubmed: 20123989
EBioMedicine. 2019 Mar;41:526-537
pubmed: 30737086
J Virol. 2003 Feb;77(4):2600-6
pubmed: 12551998
Autophagy. 2017 May 4;13(5):914-927
pubmed: 28318352
Curr Top Microbiol Immunol. 2009;335:323-33
pubmed: 19802573
Autophagy. 2008 Jan;4(1):46-53
pubmed: 18340111
Int J Mol Sci. 2019 Feb 06;20(3):
pubmed: 30736273
Nat Rev Mol Cell Biol. 2010 May;11(5):329-41
pubmed: 20379207
J Infect Dis. 2014 Sep 15;210(6):875-89
pubmed: 24652493
Pharmacol Rep. 2010 Nov-Dec;62(6):1030-40
pubmed: 21273660
Biochem Biophys Res Commun. 2017 Oct 14;492(2):236-242
pubmed: 28822762
Antiviral Res. 2010 Feb;85(2):328-45
pubmed: 19857523
J Biomed Sci. 2014 Aug 20;21:80
pubmed: 25139436
Virol J. 2005 Aug 22;2:69
pubmed: 16115318
Sci Rep. 2017 Mar 28;7:45375
pubmed: 28349961
Autophagy. 2017 Oct 3;13(10):1619-1628
pubmed: 28820286
Cell Host Microbe. 2009 Oct 22;6(4):354-66
pubmed: 19837375
Nat Rev Drug Discov. 2007 Apr;6(4):304-12
pubmed: 17396135
Cell Death Differ. 2017 Feb;24(2):317-329
pubmed: 27935582
Semin Cell Dev Biol. 2014 Dec;36:121-9
pubmed: 25158238
J Neuroinflammation. 2012 Jan 18;9:12
pubmed: 22251375
Autophagy. 2018;14(8):1435-1455
pubmed: 29940786
AIDS Res Ther. 2012 May 20;9(1):16
pubmed: 22606989
Sci Rep. 2018 Jan 11;8(1):489
pubmed: 29323257
Autophagy. 2018;14(2):243-251
pubmed: 29165043
J Neuroinflammation. 2020 Mar 20;17(1):90
pubmed: 32192500