MnSOD functions as a thermoreceptor activated by low temperature.
Bacteria
/ enzymology
Bacterial Proteins
/ chemistry
Cold Temperature
Cold-Shock Response
/ physiology
Fungal Proteins
/ chemistry
Fungi
/ enzymology
Humans
Hydrogen Peroxide
/ metabolism
Manganese
/ chemistry
Oxidative Stress
/ physiology
Protein Conformation
Signal Transduction
/ physiology
Superoxide Dismutase
/ chemistry
Superoxides
/ chemistry
Thermoreceptors
/ chemistry
Allosteric enzyme
H(2)O(2)
Manganese superoxide dismutase (MnSOD)
Second messenger
Superoxide
Thermoreceptor
Journal
Journal of inorganic biochemistry
ISSN: 1873-3344
Titre abrégé: J Inorg Biochem
Pays: United States
ID NLM: 7905788
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
22
09
2021
revised:
22
01
2022
accepted:
22
01
2022
pubmed:
6
2
2022
medline:
15
3
2022
entrez:
5
2
2022
Statut:
ppublish
Résumé
A conservative characteristic of manganese superoxide dismutase is the rapid formation of product inhibition at high temperatures. At lower temperatures, the enzyme is less inhibited and undergoes more catalytic fast cycles before being product-inhibited. The temperature-dependent kinetics could be rationalized by the temperature-dependent coordination in the conserved center of manganese superoxide dismutase. As temperature decreases, a water molecule (WAT2) approaches or even coordinates Mn as the sixth ligand to interfere with O
Identifiants
pubmed: 35121188
pii: S0162-0134(22)00034-4
doi: 10.1016/j.jinorgbio.2022.111745
pii:
doi:
Substances chimiques
Bacterial Proteins
0
Fungal Proteins
0
Superoxides
11062-77-4
Manganese
42Z2K6ZL8P
Hydrogen Peroxide
BBX060AN9V
Superoxide Dismutase
EC 1.15.1.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
111745Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.