The influence of CD26
Adolescent
Animals
Cell Communication
Cell Proliferation
Cells, Cultured
Child
Child, Preschool
Coculture Techniques
Dipeptidyl Peptidase 4
/ deficiency
Extracellular Matrix
/ metabolism
Female
Fibroblasts
/ enzymology
Heterografts
Humans
Infant
Keratinocytes
/ metabolism
Male
Rats, Nude
Regeneration
Signal Transduction
Skin Transplantation
Skin, Artificial
Time Factors
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
04 02 2022
04 02 2022
Historique:
received:
12
05
2021
accepted:
04
01
2022
entrez:
5
2
2022
pubmed:
6
2
2022
medline:
11
3
2022
Statut:
epublish
Résumé
CD26, also known as dipeptidyl peptidase IV (DPPIV), is a multifunctional transmembrane protein playing a significant role in the cutaneous wound healing processes in the mouse skin. However, only scarce data are available regarding the distribution and function of this protein in the human skin. Therefore, the aim of this study was to investigate the impact of CD26 deficiency in human primary fibroblasts on the regeneration of human tissue-engineered skin substitutes in vivo. Dermo-epidermal skin analogs, based on collagen type I hydrogels, were populated either with human CD26
Identifiants
pubmed: 35121765
doi: 10.1038/s41598-022-05309-5
pii: 10.1038/s41598-022-05309-5
pmc: PMC8816920
doi:
Substances chimiques
DPP4 protein, human
EC 3.4.14.5
Dipeptidyl Peptidase 4
EC 3.4.14.5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1944Informations de copyright
© 2022. The Author(s).
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