Seroreduction of syphilis non-treponemal titers during pregnancy for women with and without HIV co-infection.
Treponema pallidum
HIV
Zambia
pregnancy
rapid plasma reagin
serology
stillbirth
syphilis
Journal
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
ISSN: 1879-3479
Titre abrégé: Int J Gynaecol Obstet
Pays: United States
ID NLM: 0210174
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
revised:
31
01
2021
received:
16
11
2021
accepted:
03
02
2022
pubmed:
6
2
2022
medline:
12
10
2022
entrez:
5
2
2022
Statut:
ppublish
Résumé
To evaluate the effect of HIV co-infection on non-treponemal titers during pregnancy in women with syphilis. This is a secondary analysis of pregnant women with syphilis in the prospective, observational Zambian Preterm Birth Prevention Study (ZAPPS). Treponemal (Treponema pallidum particle agglutination) and non-treponemal (rapid plasma reagin; RPR) testing were performed on serum biospecimens, resulting in 47 participants with serologically confirmed syphilis (27 HIV-positive, 20 HIV-negative). The primary outcome, achievement of RPR titer seroreduction during pregnancy, was analyzed by logistic regression. Secondary outcomes included overall titer reduction, seroreduction rate, serologic cure, and adverse pregnancy outcomes. Seroreduction of RPR titer occurred in 78% (21/27) of women with HIV versus 45% (9/20) of women without (adjusted odds ratio 4.66; 95% confidence interval [CI] 1.14 - 19.08). Overall RPR titer reduction, rate of seroreduction per week, and the proportion achieving serologic cure each trended higher among women with HIV compared with those without HIV. There was a trend toward decreased stillbirth incidence in participants achieving seroreduction (odds ratio 0.15, 95% CI 0.01-1.58). HIV co-infection in this cohort of Zambian women with syphilis was associated with greater odds of RPR titer seroreduction during pregnancy. Pregnant women with syphilis and HIV may not be at increased risk for a delayed syphilis treatment response compared with women without HIV.
Identifiants
pubmed: 35122676
doi: 10.1002/ijgo.14131
pmc: PMC9516483
mid: NIHMS1834876
doi:
Substances chimiques
Reagins
0
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
427-434Subventions
Organisme : Burroughs Wellcome Fund
ID : NGP10161
Organisme : UNC Center for AIDS Research
ID : P30 AI50410
Organisme : Bill and Melinda Gates Foundation
ID : OPP1033514
Organisme : Global Alliance to Prevent Prematurity and Stillbirth
Organisme : NIAID NIH HHS
ID : P30 AI050410
Pays : United States
Organisme : FIC NIH HHS
ID : K01 TW010857
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD075731
Pays : United States
Organisme : FIC NIH HHS
ID : K01 TW010857
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD075731
Pays : United States
Informations de copyright
© 2022 International Federation of Gynecology and Obstetrics.
Références
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