Synthesis and bioactivity of readily hydrolysable novel cationic lipids for potential lung delivery application of mRNAs.
Cationic lipids
DOTAP
LNP
Lipid nanoparticles
Lung
Nebulization
mRNA
Journal
Chemistry and physics of lipids
ISSN: 1873-2941
Titre abrégé: Chem Phys Lipids
Pays: Ireland
ID NLM: 0067206
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
received:
20
08
2021
revised:
27
01
2022
accepted:
31
01
2022
pubmed:
6
2
2022
medline:
3
3
2022
entrez:
5
2
2022
Statut:
ppublish
Résumé
Lipid nanoparticles (LNPs) mediated mRNA delivery has gained prominence due to the success of mRNA vaccines against Covid-19, without which it would not have been possible. However, there is little clinical validation of this technology for other mRNA-based therapeutic approaches. Systemic administration of LNPs predominantly targets the liver, but delivery to other organs remains a challenge. Local approaches remain a viable option for some disease indications, such as Cystic Fibrosis, where aerosolized delivery to airway epithelium is the preferred route of administration. With this in mind, novel cationic lipids (L1-L4) have been designed, synthesized and co-formulated with a proprietary ionizable lipid. These LNPs were further nebulized, along with baseline control DOTAP-based LNP (DOTAP
Identifiants
pubmed: 35122738
pii: S0009-3084(22)00006-8
doi: 10.1016/j.chemphyslip.2022.105178
pmc: PMC9749011
pii:
doi:
Substances chimiques
Lipid Nanoparticles
0
Liposomes
0
RNA, Messenger
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105178Informations de copyright
Copyright © 2022 Elsevier B.V. All rights reserved.
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