Microglial Inflammation and Cognitive Dysfunction in Comorbid Rat Models of Striatal Ischemic Stroke and Alzheimer's Disease: Effects of Antioxidant Catalase-SKL on Behavioral and Cellular Pathology.

Alzheimer Disease / metabolism Amyloid beta-Peptides / metabolism Animals Antioxidants / metabolism Catalase / metabolism Cognitive Dysfunction / metabolism Disease Models, Animal Inflammation / metabolism Ischemic Stroke Maze Learning / physiology Memory Disorders / metabolism Microglia / metabolism Rats Rats, Transgenic Stroke / pathology
catalase comorbidity memory microglia activation neuroinflammation oxidative stress

Journal

Neuroscience
ISSN: 1873-7544
Titre abrégé: Neuroscience
Pays: United States
ID NLM: 7605074

Informations de publication

Date de publication:
01 04 2022
Historique:
received: 02 11 2021
revised: 26 01 2022
accepted: 28 01 2022
pubmed: 7 2 2022
medline: 14 4 2022
entrez: 6 2 2022
Statut: ppublish

Résumé

Ischemic stroke often co-occurs with Alzheimer's disease (AD) leading to a worsened clinical outcome. Neuroinflammation is a critical process implicated in AD and ischemic pathology, associated with cognitive decline. We sought to investigate the combined effects of ischemic stroke induced by endothelin-1 injection in two AD rat models, using motor function, memory and microglial inflammation in the basal forebrain and striatum as readouts. In addition, we sought to determine the effectiveness of the antioxidant biologic CAT-SKL in one of the models. The early AD model employed the bilateral intracerebroventricular injections of the toxic β-amyloid peptide Aβ

Identifiants

DOI: 10.1016/j.neuroscience.2022.01.026 PMID: 35124164
pubmed: 35124164
pii: S0306-4522(22)00047-1
doi: 10.1016/j.neuroscience.2022.01.026
pii:
doi:

Substances chimiques

Amyloid beta-Peptides 0
Antioxidants 0
Catalase EC 1.11.1.6

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

47-65

Subventions

Organisme : CIHR
ID : R1478A47
Pays : Canada

Informations de copyright

Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Auteurs

Jennifer L MacKenzie (JL)

Department of Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, Western University, London, ON N6A 5C1, Canada.

Nadezda Ivanova (N)

Department of Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, Western University, London, ON N6A 5C1, Canada. Electronic address: nivanov3@uwo.ca.

Hayley J Nell (HJ)

Department of Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, Western University, London, ON N6A 5C1, Canada.

Courtney R Giordano (CR)

Biobanking and Correlative Sciences Core, Karmanos Cancer Institute/Wayne State University, Detroit, MI 48201, USA. Electronic address: giordanoc@karmanos.org.

Stanley R Terlecky (SR)

Department of Medical Sciences, Hackensack Meridian School of Medicine, Nutley, NJ 07110, USA. Electronic address: stanley.terlecky@hmhn.org.

Cansu Agca (C)

Department of Veterinary Pathobiology, University of Missouri College of Veterinary Medicine, Columbia, MO 65211, USA. Electronic address: agcac@missouri.edu.

Yuksel Agca (Y)

Department of Veterinary Pathobiology, University of Missouri College of Veterinary Medicine, Columbia, MO 65211, USA. Electronic address: agcay@missouri.edu.

Paul A Walton (PA)

Department of Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, Western University, London, ON N6A 5C1, Canada. Electronic address: pwalton@uwo.ca.

Shawn N Whitehead (SN)

Department of Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, Western University, London, ON N6A 5C1, Canada. Electronic address: Whitehead@schulich.uwo.ca.

David F Cechetto (DF)

Department of Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, Western University, London, ON N6A 5C1, Canada. Electronic address: cechetto@uwo.ca.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Microglial Inflammation and Cognitive...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Microglial Inflammation and Cognitive...
questionsmedicales.fr › Eucaryotes › Animaux › Microglial Inflammation and Cognitive...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Microglial Inflammation and Cognitive...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Peroxidases › Catalase › Microglial Inflammation and Cognitive...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Microglial Inflammation and Cognitive...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Microglial Inflammation and Cognitive...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Microglial Inflammation and Cognitive...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Accident vasculaire cérébral › Accident vasculaire cérébral ischémique › Microglial Inflammation and Cognitive...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Apprentissage du labyrinthe › Microglial Inflammation and Cognitive...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Manifestations neurocomportementales › Troubles de la mémoire › Microglial Inflammation and Cognitive...
questionsmedicales.fr › Cellules › Névroglie › Microglie › Microglial Inflammation and Cognitive...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Microglial Inflammation and Cognitive...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rats transgéniques › Microglial Inflammation and Cognitive...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Accident vasculaire cérébral › Microglial Inflammation and Cognitive...