Impact of endolysosomal dysfunction upon exosomes in neurodegenerative diseases.
Alzheimer's disease
Endolysosomal dysfunction
Exosomes
Parkinson's disease
Pathology progression
Journal
Neurobiology of disease
ISSN: 1095-953X
Titre abrégé: Neurobiol Dis
Pays: United States
ID NLM: 9500169
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
30
09
2021
revised:
11
01
2022
accepted:
25
01
2022
pubmed:
7
2
2022
medline:
8
4
2022
entrez:
6
2
2022
Statut:
ppublish
Résumé
Although the factors contributing to the pathogenesis of neurodegenerative diseases remain elusive, endolysosomal pathway is emerging as a key player in the pathogenesis of neurodegenerative diseases. The link between endolysosomal dysfunction and neurodegeneration is supported by genetic studies identifying disease mutations in genes controlling endolysosomal function. Growing evidence suggests that endolysosomal dysfunction affect the production, secretion and content of exosomes. Current data suggests that exosomes play a key role in Parkinson's disease (PD) and Alzheimer's disease (AD) progression, interfering with the transmission of pathological proteins or neuroinflammatory factors related to neurodegenerative diseases. This review summarizes recent advances in the role of endolysosomal dysfunction in the spreading of pathological proteins mediated by exosomes in the two most common neurodegenerative diseases, AD and PD.
Identifiants
pubmed: 35124191
pii: S0969-9961(22)00042-0
doi: 10.1016/j.nbd.2022.105651
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
105651Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.