Sox6, A Potential Target for MicroRNAs in Cardiometabolic Disease.

Humans Hypertension MicroRNAs / genetics SOXD Transcription Factors / genetics
Cardiovascular diseases Diabetes Hypertension Sox6 miRNAs

Journal

Current hypertension reports
ISSN: 1534-3111
Titre abrégé: Curr Hypertens Rep
Pays: United States
ID NLM: 100888982

Informations de publication

Date de publication:
05 2022
Historique:
accepted: 18 01 2022
pubmed: 7 2 2022
medline: 1 6 2022
entrez: 6 2 2022
Statut: ppublish

Résumé

The study aims to review recent advances in knowledge on the interplay between miRNAs and the sex-determining Region Y (SRY)-related high-mobility-group box 6 (Sox6) in physiology and pathophysiology, highlighting an important role in autoimmune and cardiometabolic conditions. The transcription factor Sox6 is an important member of the SoxD family and plays an indispensable role in adult tissue homeostasis, regeneration, and physiology. Abnormal expression of the Sox6 gene has been implicated in several disease conditions including diabetes, cardiomyopathy, autoimmune diseases, and hypertension. Expression of Sox6 is regulated by miRNAs, which are RNAs of about 22 nucleotides, and have also been implicated in several pathophysiological conditions where Sox6 plays a role. Regulation of Sox6 by miRNAs is important in diverse physiological tissues and organs. Dysregulation of the interplay between miRNAs and Sox6 is an important determinant of various disease conditions and may be actionable for therapeutic purposes.

Identifiants

DOI: 10.1007/s11906-022-01175-8 PMID: 35124768
pubmed: 35124768
doi: 10.1007/s11906-022-01175-8
pii: 10.1007/s11906-022-01175-8
doi:

Substances chimiques

MicroRNAs 0
SOX6 protein, human 0
SOXD Transcription Factors 0

Types de publication

Journal Article Review Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

145-156

Subventions

Organisme : FIC NIH HHS
ID : D43 TW009337
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01HL144941
Pays : United States
Organisme : NHLBI NIH HHS
ID : R03HL155041
Pays : United States
Organisme : NHLBI NIH HHS
ID : K01 HL130497
Pays : United States

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Auteurs

Mohammad Saleem (M)

Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Room 536 Robinson Research Building, Nashville, TN, 37232-6602, USA.

Sharla Rahman (S)

Centre for Translational and Clinical Research, Jamia Hamdard, New Delhi, India.

Fernando Elijovich (F)

Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Room 536 Robinson Research Building, Nashville, TN, 37232-6602, USA.

Cheryl L Laffer (CL)

Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Room 536 Robinson Research Building, Nashville, TN, 37232-6602, USA.

Lale A Ertuglu (LA)

Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Room 536 Robinson Research Building, Nashville, TN, 37232-6602, USA.

Sepiso K Masenga (SK)

School of Medicine and Health Sciences, Mulungushi University, HAND Research Group, Livingstone, Zambia.

Annet Kirabo (A)

Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Room 536 Robinson Research Building, Nashville, TN, 37232-6602, USA. Annet.Kirabo@vumc.org.
ORCID: 0000-0001-8580-9359

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Sox6, A Potential Target for MicroRNAs in...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Hypertension artérielle › Sox6, A Potential Target for MicroRNAs in...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › Sox6, A Potential Target for MicroRNAs in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription SOX › Facteurs de transcription SOX-D › Sox6, A Potential Target for MicroRNAs in...