Interaction of Synthetic Pyrethroid Insecticide Deltamethrin with Human Alpha-2-Macroglobulin: Spectroscopic and Molecular Docking Studies.
Synthetic pyrethroids
alpha-2-macroglobulin
anti-proteinase
deltamethrin
insecticide
molecular docking
Journal
Protein and peptide letters
ISSN: 1875-5305
Titre abrégé: Protein Pept Lett
Pays: Netherlands
ID NLM: 9441434
Informations de publication
Date de publication:
2022
2022
Historique:
received:
29
09
2021
revised:
17
11
2021
accepted:
07
12
2021
pubmed:
8
2
2022
medline:
18
6
2022
entrez:
7
2
2022
Statut:
ppublish
Résumé
Deltamethrin (DLM) is a commercial insecticide of the synthetic pyrethroid family that is used to control disease-causing insects and vectors. When humans are exposed to the fumes or aerosols of DLM, it enters the body via cuticular absorption and reacts with proteins and other biomolecules. Alpha-2-macroglobulin (α Various spectroscopic techniques, including UV absorption and fluorescence spectroscopy, binding studies, and molecular docking, were used to characterize the interaction of DLM with α The UV-Vis and fluorescence spectral studies indicated the formation of a complex between α The decrease in the functional activity and structural changes of protein after binding with DLM has a significant effect on human α
Sections du résumé
BACKGROUND
BACKGROUND
Deltamethrin (DLM) is a commercial insecticide of the synthetic pyrethroid family that is used to control disease-causing insects and vectors. When humans are exposed to the fumes or aerosols of DLM, it enters the body via cuticular absorption and reacts with proteins and other biomolecules.
OBJECTIVE
OBJECTIVE
Alpha-2-macroglobulin (α
METHODS
METHODS
Various spectroscopic techniques, including UV absorption and fluorescence spectroscopy, binding studies, and molecular docking, were used to characterize the interaction of DLM with α
RESULTS
RESULTS
The UV-Vis and fluorescence spectral studies indicated the formation of a complex between α
CONCLUSION
CONCLUSIONS
The decrease in the functional activity and structural changes of protein after binding with DLM has a significant effect on human α
Identifiants
pubmed: 35125074
pii: PPL-EPUB-120647
doi: 10.2174/0929866529666220203095706
doi:
Substances chimiques
Insecticides
0
Nitriles
0
Peptide Fragments
0
Pregnancy-Associated alpha 2-Macroglobulins
0
Pyrethrins
0
decamethrin
2JTS8R821G
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
284-292Subventions
Organisme : Indian Council of Medical Research
ID : 45/18/2019-BIO- BMS
Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.