Tri-2-Hydroxyarachidonein Induces Cytocidal Autophagy in Pancreatic Ductal Adenocarcinoma Cancer Cell Models.
autophagy
cancer
cell death
oncology
pancreas
signal transduction
synthetic lipid
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2021
2021
Historique:
received:
24
09
2021
accepted:
28
10
2021
entrez:
7
2
2022
pubmed:
8
2
2022
medline:
8
2
2022
Statut:
epublish
Résumé
Cell proliferation in pancreatic cancer is determined by a complex network of signaling pathways. Despite the extensive understanding of these protein-mediated signaling processes, there are no significant drug discoveries that could considerably improve a patient's survival. However, the recent understanding of lipid-mediated signaling gives a new perspective on the control of the physiological state of pancreatic cells. Lipid signaling plays a major role in the induction of cytocidal autophagy and can be exploited using synthetic lipids to induce cell death in pancreatic cancer cells. In this work, we studied the activity of a synthetic lipid, tri-2-hydroxyarachidonein (TGM4), which is a triacylglycerol mimetic that contains three acyl moieties with four double bonds each, on cellular and
Identifiants
pubmed: 35126175
doi: 10.3389/fphys.2021.782525
pmc: PMC8811354
doi:
Types de publication
Journal Article
Langues
eng
Pagination
782525Informations de copyright
Copyright © 2022 Fernández-Díaz, Beteta-Göbel, Torres, Cabot, Fernández-García, Lladó, Escribá and Busquets.
Déclaration de conflit d'intérêts
PF-G and VL were employed by company Laminar Pharmaceuticals. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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