Short Chain Fatty Acids Taken at Time of Thrombectomy in Acute Ischemic Stroke Patients Are Independent of Stroke Severity But Associated With Inflammatory Markers and Worse Symptoms at Discharge.
Adult
Aged
Aged, 80 and over
Biomarkers
/ metabolism
Cytokines
/ metabolism
Dysbiosis
/ metabolism
Fatty Acids, Volatile
/ blood
Female
Gastrointestinal Microbiome
Humans
Inflammation
/ diagnosis
Intestinal Mucosa
/ metabolism
Ischemic Stroke
/ blood
Male
Middle Aged
Outcome Assessment, Health Care
/ methods
Patient Discharge
/ statistics & numerical data
Protein Interaction Maps
Proteome
/ metabolism
Severity of Illness Index
Thrombectomy
/ methods
brain ischemia
cytokine - immunological terms
inflammation
microbiome & dysbiosis
neuroimmunology of the gut
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
18
10
2021
accepted:
22
12
2021
entrez:
7
2
2022
pubmed:
8
2
2022
medline:
1
3
2022
Statut:
epublish
Résumé
Short chain fatty acids (SCFA) are gut microbiota-derived metabolites that contribute to the gut-brain axis and may impact stroke outcomes following gut dysbiosis. We evaluated plasma SCFA concentrations against stroke severity parameters and identified SCFA-associated protein networks. The Blood and Clot Thrombectomy Registry and Collaboration (BACTRAC), a continuously enrolling tissue bank, was used to obtain stroke samples. Arterial blood distal and proximal to the thrombus was obtained from Acute Ischemic Stroke (AIS) Patients (n=53) during thrombectomy. Patient demographics, stroke presentation and outcome parameters were reported. The SCFAs were isolated from proximal plasma Acetate positively correlated with time from last known normal (LKN) and was significantly lower in stroke patients compared to control. Isobutyrate, Butyrate and 2-Methylbutyrate negatively correlated with %ΔNIHSS. Isobutyrate and 2-Methylbutyrate positively correlated with NIHSS discharge. SCFA concentrations were not associated with NIHSS admission, infarct volume, or edema volume. Multiple SCFAs positively associated with systemic and pro-inflammatory cytokines, most notably IL-6, TNF-α, VCAM1, IL-17, and MCP-1. Plasma SCFA concentrations taken at time of stroke are not associated with stroke severity at presentation. However, higher levels of SCFAs at the time of stroke are associated with increased markers of inflammation, less recovery from admission to discharge, and worse symptom burden at discharge.
Identifiants
pubmed: 35126360
doi: 10.3389/fimmu.2021.797302
pmc: PMC8807638
doi:
Substances chimiques
Biomarkers
0
Cytokines
0
Fatty Acids, Volatile
0
Proteome
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
797302Informations de copyright
Copyright © 2022 Henry, Frank, McLouth, Trout, Morris, Chen, Stowe, Fraser and Pennypacker.
Déclaration de conflit d'intérêts
KP, JFF, and AS are cofounders of Cerelux, LLC. JC is employed by Dicerna Pharmaceuticals Inc. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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