Rationally designed foldameric adjuvants enhance antibiotic efficacy
Journal
Molecular systems design & engineering
ISSN: 2058-9689
Titre abrégé: Mol Syst Des Eng
Pays: England
ID NLM: 101683399
Informations de publication
Date de publication:
04 Jan 2022
04 Jan 2022
Historique:
received:
17
08
2021
accepted:
06
10
2021
entrez:
7
2
2022
pubmed:
8
2
2022
medline:
8
2
2022
Statut:
epublish
Résumé
The negative membrane potential of bacterial cells influences crucial cellular processes. Inspired by the molecular scaffold of the antimicrobial peptide PGLa, we have developed antimicrobial foldamers with a computer-guided design strategy. The novel PGLa analogues induce sustained membrane hyperpolarization. When co-administered as an adjuvant, the resulting compounds - PGLb1 and PGLb2 - have substantially reduced the level of antibiotic resistance of multi-drug resistant
Identifiants
pubmed: 35127141
doi: 10.1039/d1me00118c
pii: d1me00118c
pmc: PMC8724909
doi:
Types de publication
Journal Article
Langues
eng
Pagination
21-33Informations de copyright
This journal is © The Royal Society of Chemistry.
Déclaration de conflit d'intérêts
There are no conflicts to declare.
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