Pharmaceutical applications of framework nucleic acids.
DNA nanostructures
DNA nanotechnology
Drug analysis
Drug delivery
Drug discovery
Framework nucleic acids
Self-assembly
Therapeutic molecules
Journal
Acta pharmaceutica Sinica. B
ISSN: 2211-3835
Titre abrégé: Acta Pharm Sin B
Pays: Netherlands
ID NLM: 101600560
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
14
04
2021
revised:
08
05
2021
accepted:
11
05
2021
entrez:
7
2
2022
pubmed:
8
2
2022
medline:
8
2
2022
Statut:
ppublish
Résumé
DNA is a biological polymer that encodes and stores genetic information in all living organism. Particularly, the precise nucleobase pairing inside DNA is exploited for the self-assembling of nanostructures with defined size, shape and functionality. These DNA nanostructures are known as framework nucleic acids (FNAs) for their skeleton-like features. Recently, FNAs have been explored in various fields ranging from physics, chemistry to biology. In this review, we mainly focus on the recent progress of FNAs in a pharmaceutical perspective. We summarize the advantages and applications of FNAs for drug discovery, drug delivery and drug analysis. We further discuss the drawbacks of FNAs and provide an outlook on the pharmaceutical research direction of FNAs in the future.
Identifiants
pubmed: 35127373
doi: 10.1016/j.apsb.2021.05.022
pii: S2211-3835(21)00188-X
pmc: PMC8799870
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
76-91Informations de copyright
© 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
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