Signaling Pathways Mediating Bradykinin-Induced Contraction in Murine and Human Detrusor Muscle.
Rho-kinase
bradykinin
detrusor reactivity
signal transduction
urinary bladder smooth muscle
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2021
2021
Historique:
received:
22
07
2021
accepted:
23
12
2021
entrez:
7
2
2022
pubmed:
8
2
2022
medline:
8
2
2022
Statut:
epublish
Résumé
Bradykinin (BK) has been proposed to modulate urinary bladder functions and implicated in the pathophysiology of detrusor overactivity. The present study aims to elucidate the signaling pathways of BK-induced detrusor muscle contraction, with the goal of better understanding the molecular regulation of micturition and identifying potential novel therapeutic targets of its disorders. Experiments have been carried out on bladders isolated from wild-type or genetically modified [smooth muscle-specific knockout (KO): Gα
Identifiants
pubmed: 35127739
doi: 10.3389/fmed.2021.745638
pmc: PMC8811450
doi:
Banques de données
figshare
['10.6084/m9.figshare.16815061.v5']
Types de publication
Journal Article
Langues
eng
Pagination
745638Informations de copyright
Copyright © 2022 Borsodi, Balla, Molnár, Lénárt, Kenessey, Horváth, Keszthelyi, Romics, Majoros, Nyirády, Offermanns and Benyó.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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