The interplay between SARS-CoV-2 infected airway epithelium and immune cells modulates regulatory/inflammatory signals.
Immunology
Virology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
18 Feb 2022
18 Feb 2022
Historique:
received:
19
11
2021
revised:
21
12
2021
accepted:
27
01
2022
pubmed:
8
2
2022
medline:
8
2
2022
entrez:
7
2
2022
Statut:
ppublish
Résumé
To assess the cross-talk between immune cells and respiratory tract during SARS-CoV-2 infection, we analyzed the relationships between the inflammatory response induced by SARS-CoV-2 replication and immune cells phenotype in a reconstituted organotypic human airway epithelium (HAE). The results indicated that immune cells failed to inhibit SARS-CoV-2 replication in the HAE model. In contrast, immune cells strongly affected the inflammatory profile induced by SARS-CoV-2 infection, dampening the production of several immunoregulatory/inflammatory signals (e.g., IL-35, IL-27, and IL-34). Moreover, these mediators were found inversely correlated with innate immune cell frequency (NK and γδ T cells) and directly with CD8 T cells. The enriched signals associated with NK and CD8 T cells highlighted the modulation of pathways induced by SARS-CoV-2 infected HAE. These findings are useful to depict the cell-cell communication mechanisms necessary to develop novel therapeutic strategies aimed to promote an effective immune response.
Identifiants
pubmed: 35128349
doi: 10.1016/j.isci.2022.103854
pii: S2589-0042(22)00124-9
pmc: PMC8802491
doi:
Types de publication
Journal Article
Langues
eng
Pagination
103854Informations de copyright
© 2022 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no competing interests.
Références
J Cell Mol Med. 2020 Oct;24(19):11603-11606
pubmed: 32864865
Lancet Respir Med. 2020 Apr;8(4):420-422
pubmed: 32085846
N Engl J Med. 2020 Feb 20;382(8):727-733
pubmed: 31978945
Nat Commun. 2020 Oct 16;11(1):5243
pubmed: 33067472
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
Cell Rep Med. 2020 Jul 21;1(4):100059
pubmed: 32835306
Sci Rep. 2018 Jan 11;8(1):418
pubmed: 29323162
Nat Commun. 2020 Jul 8;11(1):3410
pubmed: 32641700
Mucosal Immunol. 2019 May;12(3):589-600
pubmed: 30874596
Mol Syst Biol. 2020 Jul;16(7):e9841
pubmed: 32715628
Nat Commun. 2020 Aug 6;11(1):3910
pubmed: 32764693
Cytokine. 2016 May;81:23-7
pubmed: 26844658
Lancet. 2020 Mar 28;395(10229):1033-1034
pubmed: 32192578
mBio. 2020 Nov 6;11(6):
pubmed: 33158999
Int Immunopharmacol. 2018 Aug;61:119-125
pubmed: 29857241
Nat Med. 2020 Jun;26(6):842-844
pubmed: 32398875
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
J Infect Dis. 2006 May 1;193(9):1244-9
pubmed: 16586361
Clin Infect Dis. 2020 Nov 19;71(16):2272-2275
pubmed: 32407466
Nat Genet. 2020 Dec;52(12):1283-1293
pubmed: 33077916
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
PLoS Biol. 2021 Mar 17;19(3):e3001143
pubmed: 33730024
J Biol Chem. 2009 Mar 6;284(10):6486-94
pubmed: 19122199
Nat Biotechnol. 2020 Aug;38(8):970-979
pubmed: 32591762
Cell. 2020 May 28;181(5):1036-1045.e9
pubmed: 32416070
Thorax. 2013 Jan;68(1):76-81
pubmed: 23002173
J Clin Med. 2021 May 08;10(9):
pubmed: 34066892
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Mod Pathol. 2020 Jun;33(6):1007-1014
pubmed: 32291399
PLoS Pathog. 2014 May 08;10(5):e1004110
pubmed: 24809349
Science. 2020 Aug 7;369(6504):718-724
pubmed: 32661059