Evaluation of oxidative stress in seminal plasma of adolescents with varicocele.
adolescent
antioxidants
oxidative stress
seminal analysis
varicocele
Journal
Reproduction & fertility
ISSN: 2633-8386
Titre abrégé: Reprod Fertil
Pays: England
ID NLM: 101778727
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
16
04
2021
accepted:
06
05
2021
entrez:
7
2
2022
pubmed:
8
2
2022
medline:
8
2
2022
Statut:
epublish
Résumé
Varicocele, defined by a dilation of efferent testicular veins, is the most commonly identifiable, surgically correctable lesion associated with male-factor infertility, starts at puberty and causes a progressive decline in fertility potential. The pathophysiology of infertility caused by this disease is still poorly understood, but it is suggested that the main mechanism is oxidative stress. Therefore, the aim of this study was to verify if the varicocele is associated with changes in enzymatic antioxidant mechanisms and seminal plasma lipid peroxidation levels in adolescents. We recruited 90 adolescents that were divided into control (C; Varicocele, defined by a dilation of efferent testicular veins, is the most commonly identifiable, surgically correctable lesion associated with male-factor infertility, starts at puberty and causes a progressive decline in fertile potential. There is still much that is not understood regarding how exactly it affects semen quality, but most studies agree that oxidative stress, which is defined as excessive amounts of free radicals in relation to antioxidant defense, is an important mechanism. In this study, we aimed to verify if the varicocele is associated with changes in antioxidant defense and semen oxidation in 90 adolescents with and without varicocele. In adolescents with varicocele and abnormal semen, there is an increase in semen oxidation compared to controls or to the group with varicocele and normal semen quality. Our results can help to understand how varicocele leads to infertility in adolescents, identifying changes in oxidative activity in semen, since the onset of varicocele and before damage to sperm production can be detected.
Identifiants
pubmed: 35128449
doi: 10.1530/RAF-20-0048
pii: RAF-20-0048
pmc: PMC8812440
doi:
Substances chimiques
Antioxidants
0
Glutathione Peroxidase
EC 1.11.1.9
Superoxide Dismutase
EC 1.15.1.1
Types de publication
Journal Article
Langues
eng
Pagination
141-150Informations de copyright
© The authors.
Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.
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