Direct Dehydrogenative Access to Unsymmetrical Phenones.
Arylation
Cross Dehydrogenative Coupling
C−H Functionalization
Electrochemistry
Hexafluoroisopropanol
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
09 05 2022
09 05 2022
Historique:
received:
24
01
2022
pubmed:
8
2
2022
medline:
4
5
2022
entrez:
7
2
2022
Statut:
ppublish
Résumé
The first non-directed dehydrogenative phenone coupling method of methylarenes with aromatic C-H bonds, displaying a large substrate scope, is herein reported. This reaction represents a far more direct atom- and step-efficient alternative to the classical Friedel-Crafts or Suzuki-Miyaura derived acylation reactions. The method can be carried out on a gram scale and was successfully applied to the synthesis of several Ketoprofen drug analogues.
Identifiants
pubmed: 35128810
doi: 10.1002/anie.202201142
pmc: PMC9314079
doi:
Substances chimiques
Ketones
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202201142Informations de copyright
© 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.
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