Non-invasive quantification of acute macrophagic lung inflammation with [
Acute respiratory distress syndrome
Inflammation
Positron emission tomography
Tissue compartment kinetic model
Ventilator-induced lung injury
[11C](R)-PK11195
Journal
European journal of nuclear medicine and molecular imaging
ISSN: 1619-7089
Titre abrégé: Eur J Nucl Med Mol Imaging
Pays: Germany
ID NLM: 101140988
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
23
09
2021
accepted:
30
01
2022
pubmed:
8
2
2022
medline:
26
5
2022
entrez:
7
2
2022
Statut:
ppublish
Résumé
Imaging of acute lung inflammation is pivotal to evaluate innovative ventilation strategies. We aimed to develop and validate a three-tissue compartment kinetic model (3TCM) of [ We analyzed the data of 38 positron emission tomography (PET) studies performed in 21 swine with or without experimental ARDS, receiving general anesthesia and mechanical ventilation. Model input function was a plasma, metabolite-corrected, image-derived input function measured in the main pulmonary artery. Regional lung analysis consisted in applying both the 3TCM and the two-tissue compartment model (2TCM); in each region, the best model was selected using a selection algorithm with a goodness-of-fit criterion. Regional best model binding potentials (BP The 3TCM was preferred in 142 lung regions (62%, 95% confidence interval: 56 to 69%). BP To assess the intensity and spatial distribution of acute macrophagic lung inflammation in the context of experimental ARDS with mechanical ventilation, PET quantification of [
Identifiants
pubmed: 35129652
doi: 10.1007/s00259-022-05713-z
pii: 10.1007/s00259-022-05713-z
doi:
Substances chimiques
Isoquinolines
0
PK 11195
YNF83VN1RL
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2122-2136Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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