CDNF and MANF regulate ER stress in a tissue-specific manner.

Animals Dopaminergic Neurons / metabolism Endoplasmic Reticulum / metabolism Endoplasmic Reticulum Stress Female Male Mice Mice, Inbred C57BL Mice, Knockout Nerve Growth Factors / metabolism Neurodegenerative Diseases / metabolism Unfolded Protein Response
CDNF Dopamine ER stress MANF UPR

Journal

Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402

Informations de publication

Date de publication:
07 Feb 2022
Historique:
received: 10 06 2021
accepted: 19 01 2022
revised: 11 01 2022
entrez: 7 2 2022
pubmed: 8 2 2022
medline: 22 2 2022
Statut: epublish

Résumé

Cerebral dopamine neurotrophic factor (CDNF) and mesencephalic astrocyte-derived neurotrophic factor (MANF) display cytoprotective effects in animal models of neurodegenerative diseases. These endoplasmic reticulum (ER)-resident proteins belong to the same protein family and function as ER stress regulators. The relationship between CDNF and MANF function, as well as their capability for functional compensation, is unknown. We aimed to investigate these questions by generating mice lacking both CDNF and MANF. Results showed that CDNF-deficient Manf

Identifiants

DOI: 10.1007/s00018-022-04157-w PMID: 35129674 PMC: PMC8821067
pubmed: 35129674
doi: 10.1007/s00018-022-04157-w
pii: 10.1007/s00018-022-04157-w
pmc: PMC8821067
doi:

Substances chimiques

MANF protein, mouse 0
Nerve Growth Factors 0
cdnf protein, mouse 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

124

Subventions

Organisme : Academy of Finland
ID : 1310891
Organisme : Academy of Finland
ID : 117044

Informations de copyright

© 2022. The Author(s).

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Auteurs

Emmi Pakarinen (E)

Institute of Biotechnology, HiLIFE Unit, University of Helsinki, 00014, Helsinki, Finland.

Päivi Lindholm (P)

Institute of Biotechnology, HiLIFE Unit, University of Helsinki, 00014, Helsinki, Finland.
ORCID: 0000-0003-3022-5035

Mart Saarma (M)

Institute of Biotechnology, HiLIFE Unit, University of Helsinki, 00014, Helsinki, Finland.
ORCID: 0000-0001-5543-7160

Maria Lindahl (M)

Institute of Biotechnology, HiLIFE Unit, University of Helsinki, 00014, Helsinki, Finland. maria.lindahl@helsinki.fi.
ORCID: 0000-0002-5674-8830

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › CDNF and MANF regulate ER stress in a...
questionsmedicales.fr › Cellules › Neurones › Neurones dopaminergiques › CDNF and MANF regulate ER stress in a...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Réticulum endoplasmique › CDNF and MANF regulate ER stress in a...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Stress du réticulum endoplasmique › CDNF and MANF regulate ER stress in a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › CDNF and MANF regulate ER stress in a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › CDNF and MANF regulate ER stress in a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › CDNF and MANF regulate ER stress in a...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Facteurs de croissance nerveuse › CDNF and MANF regulate ER stress in a...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › CDNF and MANF regulate ER stress in a...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › Réponse aux protéines mal repliées › CDNF and MANF regulate ER stress in a...