GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas.

Astrocytoma / genetics Brain Stem Neoplasms / genetics Child Gangliosides / immunology Gene Expression Profiling Glioma / genetics Histones / genetics Humans Immunotherapy, Adoptive / methods Mutation Receptors, Chimeric Antigen / immunology Spinal Cord Neoplasms / genetics

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
03 2022
Historique:
received: 02 08 2021
accepted: 28 01 2022
pubmed: 8 2 2022
medline: 16 4 2022
entrez: 7 2 2022
Statut: ppublish

Résumé

Diffuse intrinsic pontine glioma (DIPG) and other H3K27M-mutated diffuse midline gliomas (DMGs) are universally lethal paediatric tumours of the central nervous system

Identifiants

DOI: 10.1038/s41586-022-04489-4 PMID: 35130560 PMC: PMC8967714
pubmed: 35130560
doi: 10.1038/s41586-022-04489-4
pii: 10.1038/s41586-022-04489-4
pmc: PMC8967714
doi:

Substances chimiques

Gangliosides 0
Histones 0
Receptors, Chimeric Antigen 0
sialogangliosides 0

Types de publication

Clinical Trial, Phase I Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

934-941

Subventions

Organisme : NINDS NIH HHS
ID : DP1 NS111132
Pays : United States
Organisme : NCI NIH HHS
ID : DP2 CA272092
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA124435
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA263500
Pays : United States

Informations de copyright

© 2022. The Author(s).

Références

Louis, D. N. et al. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol. 131, 803–820 (2016).
pubmed: 27157931 doi: 10.1007/s00401-016-1545-1
Mount, C. W. et al. Potent antitumor efficacy of anti-GD2 CAR T cells in H3-K27M
pubmed: 29662203 pmcid: 6214371 doi: 10.1038/s41591-018-0006-x
Theruvath, J. et al. Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors. Nat. Med. 26, 712–719 (2020).
pubmed: 32341579 pmcid: 7992505 doi: 10.1038/s41591-020-0821-8
Lin, G. L. et al. Non-inflammatory tumor microenvironment of diffuse intrinsic pontine glioma. Acta Neuropathol. Commun. 6, 51 (2018).
pubmed: 29954445 pmcid: 6022714 doi: 10.1186/s40478-018-0553-x
Broniscer, A. et al. Intratumoral hemorrhage among children with newly diagnosed, diffuse brainstem glioma. Cancer 106, 1364–1371 (2006).
pubmed: 16463390 doi: 10.1002/cncr.21749
Brown, C. E. et al. Regression of glioblastoma after chimeric antigen receptor T-cell therapy. N. Engl. J. Med. 375, 2561–2569 (2016).
pubmed: 28029927 pmcid: 5390684 doi: 10.1056/NEJMoa1610497
Ahmed, N. et al. HER2-specific chimeric antigen receptor-modified virus-specific T cells for progressive glioblastoma: a phase 1 dose-escalation trial. JAMA Oncol. 3, 1094–1101 (2017).
pubmed: 28426845 pmcid: 5747970 doi: 10.1001/jamaoncol.2017.0184
Weber, E. W. et al. Pharmacologic control of CAR-T cell function using dasatinib. Blood Adv. 3, 711–717 (2019).
pubmed: 30814055 pmcid: 6418502 doi: 10.1182/bloodadvances.2018028720
Stallard, S. et al. CSF H3F3A K27M circulating tumor DNA copy number quantifies tumor growth and in vitro treatment response. Acta Neuropathol. Commun. 6, 80 (2018).
pubmed: 30111355 pmcid: 6094898 doi: 10.1186/s40478-018-0580-7
Fry, T. J. et al. CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy. Nat. Med. 24, 20–28 (2018).
pubmed: 29155426 doi: 10.1038/nm.4441
Lee, D. W. et al. T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial. Lancet 385, 517–528 (2015).
pubmed: 25319501 doi: 10.1016/S0140-6736(14)61403-3
Maude, S. L. et al. Chimeric antigen receptor T cells for sustained remissions in leukemia. N. Engl. J. Med. 371, 1507–1517 (2014).
pubmed: 25317870 pmcid: 4267531 doi: 10.1056/NEJMoa1407222
Walker, A. J. et al. Tumor antigen and receptor densities regulate efficacy of a chimeric antigen receptor targeting anaplastic lymphoma kinase. Mol. Ther. 25, 2189–2201 (2017).
pubmed: 28676342 pmcid: 5589087 doi: 10.1016/j.ymthe.2017.06.008
Long, A. H. et al. 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors. Nat. Med. 21, 581–590 (2015).
pubmed: 25939063 pmcid: 4458184 doi: 10.1038/nm.3838
Keren-Shaul, H. et al. A unique microglia type associated with restricting development of Alzheimer’s disease. Cell 169, 1276–1290.e17 (2017).
pubmed: 28602351 doi: 10.1016/j.cell.2017.05.018
Hammond, T. R. et al. Single-cell RNA sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes. Immunity 50, 253–271.e6 (2019).
pubmed: 30471926 doi: 10.1016/j.immuni.2018.11.004
Cooney, T. et al. Contemporary survival endpoints: an International Diffuse Intrinsic Pontine Glioma Registry study. Neuro-Oncol. 19, 1279–1280 (2017).
pubmed: 28821206 pmcid: 5570207 doi: 10.1093/neuonc/nox107
Robison, N. J. & Kieran, M. W. Diffuse intrinsic pontine glioma: a reassessment. J. Neurooncol. 119, 7–15 (2014).
pubmed: 24792486 doi: 10.1007/s11060-014-1448-8
Lee, D. W. et al. ASTCT consensus grading for cytokine release syndrome and neurologic toxicity associated with immune effector cells. Biol. Blood Marrow Transplant. 25, 625–638 (2019).
pubmed: 30592986 doi: 10.1016/j.bbmt.2018.12.758
Brudno, J. N. & Kochenderfer, J. N. Toxicities of chimeric antigen receptor T cells: recognition and management. Blood 127, 3321–3330 (2016).
pubmed: 27207799 pmcid: 4929924 doi: 10.1182/blood-2016-04-703751
Marconi, S. et al. Expression of gangliosides on glial and neuronal cells in normal and pathological adult human brain. J. Neuroimmunol. 170, 115–121 (2005).
pubmed: 16313974 doi: 10.1016/j.jneuroim.2005.03.025
Yu, A. L. et al. Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma. N. Engl. J. Med. 363, 1324–1334 (2010).
pubmed: 20879881 pmcid: 3086629 doi: 10.1056/NEJMoa0911123
Louis, C. U. et al. Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma. Blood 118, 6050–6056 (2011).
pubmed: 21984804 pmcid: 3234664 doi: 10.1182/blood-2011-05-354449
Pule, M. A. et al. Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma. Nat. Med. 14, 1264–1270 (2008).
pubmed: 18978797 pmcid: 2749734 doi: 10.1038/nm.1882
Straathof, K. et al. Antitumor activity without on-target off-tumor toxicity of GD2-chimeric antigen receptor T cells in patients with neuroblastoma. Sci. Transl. Med. 12, eabd6169 (2020).
pubmed: 33239386 doi: 10.1126/scitranslmed.abd6169
Heczey, A. et al. Anti-GD2 CAR-NKT cells in patients with relapsed or refractory neuroblastoma: an interim analysis. Nat. Med. 26, 1686–1690 (2020).
pubmed: 33046868 doi: 10.1038/s41591-020-1074-2
Majzner, R. G. et al. Tuning the antigen density requirement for CAR T-cell activity. Cancer Discov. 10, 702–723 (2020).
pubmed: 32193224 pmcid: 7939454 doi: 10.1158/2159-8290.CD-19-0945
Majzner, R. G. et al. CAR T cells targeting B7-H3, a pan-cancer antigen, demonstrate potent preclinical activity against pediatric solid tumors and brain tumors. Clin. Cancer Res. 25, 2560–2574 (2019).
pubmed: 30655315 pmcid: 8456711 doi: 10.1158/1078-0432.CCR-18-0432
Venkatesh, H. S. et al. Electrical and synaptic integration of glioma into neural circuits. Nature 573, 539–545 (2019).
pubmed: 31534222 pmcid: 7038898 doi: 10.1038/s41586-019-1563-y
Di Stasi, A. et al. Inducible apoptosis as a safety switch for adoptive cell therapy. N. Engl. J. Med. 365, 1673–1683 (2011).
pubmed: 22047558 pmcid: 3236370 doi: 10.1056/NEJMoa1106152
Weber, E. W. et al. Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling. Science 372, eaba1786 (2021).
pubmed: 33795428 pmcid: 8049103 doi: 10.1126/science.aba1786
Shen, W., Le, S., Li, Y. & Hu, F. SeqKit: a cross-platform and ultrafast toolkit for FASTA/Q file manipulation. PLoS ONE 11, e0163962 (2016).
pubmed: 27706213 pmcid: 5051824 doi: 10.1371/journal.pone.0163962
Stuart, T. et al. Comprehensive integration of single-cell data. Cell 177, 1888–1902.e21 (2019).
pubmed: 31178118 pmcid: 6687398 doi: 10.1016/j.cell.2019.05.031
Hafemeister, C. & Satija, R. Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression. Genome Biol. 20, 296 (2019).
pubmed: 31870423 pmcid: 6927181 doi: 10.1186/s13059-019-1874-1
Hao, Y. et al. Integrated analysis of multimodal single-cell data. Cell 184, 3573–3587.e29 (2021).
pubmed: 34062119 pmcid: 8238499 doi: 10.1016/j.cell.2021.04.048
Becht, E. et al. Dimensionality reduction for visualizing single-cell data using UMAP. Nat. Biotechnol. 37, 38–44 (2019).
doi: 10.1038/nbt.4314
Krasemann, S. et al. The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases. Immunity 47, 566–581.e9 (2017).
pubmed: 28930663 pmcid: 5719893 doi: 10.1016/j.immuni.2017.08.008
Li, Q. et al. Developmental heterogeneity of microglia and brain myeloid cells revealed by deep single-cell RNA sequencing. Neuron 101, 207–223.e10 (2019).
pubmed: 30606613 doi: 10.1016/j.neuron.2018.12.006
Gabrusiewicz, K., Colwell, N. A. & Heimberger, A. B. in Translational Immunotherapy of Brain Tumors (ed. Sampson, J. H.) 63–82 (2017).
Blighe, K., Rana, S. & Lewis, M. EnhancedVolcano: Publication-ready volcano plots with enhanced colouring and labeling. R package version 1.12.0. GitHub https://github.com/kevinblighe/EnhancedVolcano (2021).
Yu, G. & He, Q. Y. ReactomePA: an R/Bioconductor package for reactome pathway analysis and visualization. Mol. Biosyst. 12, 477–479 (2016).
pubmed: 26661513 doi: 10.1039/C5MB00663E
Gojo, J. et al. Single-cell RNA-seq reveals cellular hierarchies and impaired developmental trajectories in pediatric ependymoma. Cancer Cell 38, 44–59.e9 (2020).
pubmed: 32663469 pmcid: 7479515 doi: 10.1016/j.ccell.2020.06.004
Korsunsky, I. et al. Fast, sensitive and accurate integration of single-cell data with Harmony. Nat. Methods 16, 1289–1296 (2019).
pubmed: 31740819 pmcid: 6884693 doi: 10.1038/s41592-019-0619-0
Pombo Antunes, A. R. et al. Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization. Nat. Neurosci. 24, 595–610 (2021).
pubmed: 33782623 doi: 10.1038/s41593-020-00789-y
Lin, G. L. & Monje, M. A protocol for rapid post-mortem cell culture of diffuse intrinsic pontine glioma (DIPG). J. Vis. Exp. 121, 55360 (2017).

Auteurs

Robbie G Majzner (RG)

Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Division of Pediatric Hematology, Oncology, Stem Cell Transplantation & Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.
Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA.
ORCID: 0000-0001-6969-8011

Sneha Ramakrishna (S)

Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Division of Pediatric Hematology, Oncology, Stem Cell Transplantation & Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.

Kristen W Yeom (KW)

Division of Neuroradiology, Department of Radiology, Stanford University, Stanford, CA, USA.
ORCID: 0000-0001-9860-3368

Shabnum Patel (S)

Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.

Harshini Chinnasamy (H)

Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.

Liora M Schultz (LM)

Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Division of Pediatric Hematology, Oncology, Stem Cell Transplantation & Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.

Rebecca M Richards (RM)

Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Division of Pediatric Hematology, Oncology, Stem Cell Transplantation & Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.

Li Jiang (L)

Division of Pediatric Neuro-Oncology, Dana Farber Cancer Institute, Boston, MA, USA.

Valentin Barsan (V)

Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Division of Pediatric Hematology, Oncology, Stem Cell Transplantation & Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.

Rebecca Mancusi (R)

Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
ORCID: 0000-0002-4809-5569

Anna C Geraghty (AC)

Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.

Zinaida Good (Z)

Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA.
Department of Biomedical Data Science, Stanford University, Stanford, CA, USA.
ORCID: 0000-0003-2343-5771

Aaron Y Mochizuki (AY)

Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
ORCID: 0000-0003-1073-916X

Shawn M Gillespie (SM)

Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.

Angus Martin Shaw Toland (AMS)

Department of Pathology, Stanford University, Stanford, CA, USA.

Jasia Mahdi (J)

Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.

Agnes Reschke (A)

Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Division of Pediatric Hematology, Oncology, Stem Cell Transplantation & Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.

Esther H Nie (EH)

Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.

Isabelle J Chau (IJ)

Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.

Maria Caterina Rotiroti (MC)

Division of Pediatric Hematology, Oncology, Stem Cell Transplantation & Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.

Christopher W Mount (CW)

Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.

Christina Baggott (C)

Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.

Sharon Mavroukakis (S)

Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.

Emily Egeler (E)

Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.

Jennifer Moon (J)

Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.

Courtney Erickson (C)

Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.

Sean Green (S)

Division of Pediatric Hematology, Oncology, Stem Cell Transplantation & Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.

Michael Kunicki (M)

Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Division of Pediatric Hematology, Oncology, Stem Cell Transplantation & Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.
ORCID: 0000-0001-6630-6289

Michelle Fujimoto (M)

Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Division of Pediatric Hematology, Oncology, Stem Cell Transplantation & Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.

Zach Ehlinger (Z)

Division of Pediatric Hematology, Oncology, Stem Cell Transplantation & Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.

Warren Reynolds (W)

Division of Pediatric Hematology, Oncology, Stem Cell Transplantation & Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.

Sreevidya Kurra (S)

Division of Pediatric Hematology, Oncology, Stem Cell Transplantation & Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.

Katherine E Warren (KE)

Division of Pediatric Neuro-Oncology, Dana Farber Cancer Institute, Boston, MA, USA.

Snehit Prabhu (S)

Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.

Hannes Vogel (H)

Department of Pathology, Stanford University, Stanford, CA, USA.

Lindsey Rasmussen (L)

Division of Critical Care Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.

Timothy T Cornell (TT)

Division of Critical Care Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.

Sonia Partap (S)

Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.

Paul G Fisher (PG)

Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
ORCID: 0000-0002-1196-1590

Cynthia J Campen (CJ)

Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
ORCID: 0000-0002-3519-1375

Mariella G Filbin (MG)

Division of Pediatric Neuro-Oncology, Dana Farber Cancer Institute, Boston, MA, USA.

Gerald Grant (G)

Department of Neurosurgery, Stanford University, Stanford, CA, USA.

Bita Sahaf (B)

Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Division of Pediatric Hematology, Oncology, Stem Cell Transplantation & Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.

Kara L Davis (KL)

Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Division of Pediatric Hematology, Oncology, Stem Cell Transplantation & Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.
ORCID: 0000-0002-7182-2592

Steven A Feldman (SA)

Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.

Crystal L Mackall (CL)

Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA. cmackall@stanford.edu.
Division of Pediatric Hematology, Oncology, Stem Cell Transplantation & Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA. cmackall@stanford.edu.
Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. cmackall@stanford.edu.
Division of Stem Cell Transplantation and Cell Therapy, Department of Medicine, Stanford University, Stanford, CA, USA. cmackall@stanford.edu.
ORCID: 0000-0001-6323-4304

Michelle Monje (M)

Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA. mmonje@stanford.edu.
Division of Pediatric Hematology, Oncology, Stem Cell Transplantation & Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA. mmonje@stanford.edu.
Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA. mmonje@stanford.edu.
Department of Pathology, Stanford University, Stanford, CA, USA. mmonje@stanford.edu.
Department of Neurosurgery, Stanford University, Stanford, CA, USA. mmonje@stanford.edu.
Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA. mmonje@stanford.edu.
ORCID: 0000-0002-3547-237X

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › Astrocytome › GD2-CAR T cell therapy for H3K27M-mutated...
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › Tumeurs sous-tentorielles › Tumeurs du tronc cérébral › GD2-CAR T cell therapy for H3K27M-mutated...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › GD2-CAR T cell therapy for H3K27M-mutated...
questionsmedicales.fr › Lipides › Lipides membranaires › Sphingolipides › Glycosphingolipides › Glycosphingolipides acides › Gangliosides › GD2-CAR T cell therapy for H3K27M-mutated...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › GD2-CAR T cell therapy for H3K27M-mutated...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › GD2-CAR T cell therapy for H3K27M-mutated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › GD2-CAR T cell therapy for H3K27M-mutated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › GD2-CAR T cell therapy for H3K27M-mutated...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunisation passive › Transfert adoptif › Immunothérapie adoptive › GD2-CAR T cell therapy for H3K27M-mutated...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › GD2-CAR T cell therapy for H3K27M-mutated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteurs chimériques pour l'antigène › GD2-CAR T cell therapy for H3K27M-mutated...
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs de la moelle épinière › GD2-CAR T cell therapy for H3K27M-mutated...