Lab-on-a-Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics.
bioelectronics
biosensors
contact lens
diagnostics
integrated systems
personalized healthcare
therapeutics
wearable electronics
Journal
Advanced materials (Deerfield Beach, Fla.)
ISSN: 1521-4095
Titre abrégé: Adv Mater
Pays: Germany
ID NLM: 9885358
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
revised:
27
01
2022
received:
19
10
2021
pubmed:
8
2
2022
medline:
18
6
2022
entrez:
7
2
2022
Statut:
ppublish
Résumé
The eye is one of the most complex organs in the human body, containing rich and critical physiological information (e.g., intraocular pressure, corneal temperature, and pH) as well as a library of metabolite biomarkers (e.g., glucose, proteins, and specific ions). Smart contact lenses (SCLs) can serve as a wearable intelligent ocular prosthetic device capable of noninvasive and continuous monitoring of various essential physical/biochemical parameters and drug loading/delivery for the treatment of ocular diseases. Advances in SCL technologies and the growing public interest in personalized health are accelerating SCL research more than ever before. Here, the current status and potential of SCL development through a comprehensive review from fabrication to applications to commercialization are discussed. First, the material, fabrication, and platform designs of the SCLs for the diagnostic and therapeutic applications are discussed. Then, the latest advances in diagnostic and therapeutic SCLs for clinical translation are reviewed. Later, the established techniques for wearable power transfer and wireless data transmission applied to current SCL devices are summarized. An outlook, future opportunities, and challenges for developing next-generation SCL devices are also provided. With the rise in interest of SCL development, this comprehensive and essential review can serve as a new paradigm for the SCL devices.
Identifiants
pubmed: 35130584
doi: 10.1002/adma.202108389
pmc: PMC9233032
mid: NIHMS1797695
doi:
Substances chimiques
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2108389Subventions
Organisme : NCI NIH HHS
ID : U01 CA214411
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR074234
Pays : United States
Organisme : NIH HHS
ID : CA214411
Pays : United States
Organisme : NIH HHS
ID : GM126571
Pays : United States
Organisme : NCATS NIH HHS
ID : UH3 TR003148
Pays : United States
Organisme : NCATS NIH HHS
ID : UG3 TR003148
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM126571
Pays : United States
Organisme : NIH HHS
ID : TR003148
Pays : United States
Organisme : NIH HHS
ID : AR074234
Pays : United States
Informations de copyright
© 2022 Wiley-VCH GmbH.
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