Multisystemic inflammatory syndrome related to COVID-19, with latent tuberculosis in bone marrow, and satisfactory response to tocilizumab, in a 7-year-old boy.


Journal

Reumatismo
ISSN: 0048-7449
Titre abrégé: Reumatismo
Pays: Italy
ID NLM: 0401302

Informations de publication

Date de publication:
07 Feb 2022
Historique:
received: 15 08 2021
accepted: 11 11 2021
entrez: 8 2 2022
pubmed: 9 2 2022
medline: 10 2 2022
Statut: epublish

Résumé

Paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS) or multisystem inflammatory syndrome in children (MIS-C) is a new acute-onset systemic inflammatory disease, which mainly affects children. Latent tuberculosis infection (LTBI) is characterized by the presence of immune sensitization to Mycobacterium tuberculosis (MTB) in the absence of any clinical or radiological evidence of active disease. We present a child with MIS-C related to COVID-19, with latent TB in the bone marrow, and satisfactory response to tocilizumab. It is important to pay attention in the investigation of TB cases in countries with a high prevalence of tuberculosis, especially when opting for immunusuppression.

Identifiants

pubmed: 35130686
doi: 10.4081/reumatismo.2021.1448
doi:

Substances chimiques

Antibodies, Monoclonal, Humanized 0
tocilizumab I031V2H011

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Z Morel (Z)

Pediatric Rheumatology, Pediatric Department, Central Hospital of the Social Welfare Institute, Asunción. zoiloma@hotmail.com.

R Suarez (R)

Pediatrics, Pediatric Department, Central Hospital of the Social Welfare Institute, Asunción. zoiloma@hotmail.com.

E Avalos (E)

Pediatrics, Pediatric Department, Central Hospital of the Social Welfare Institute, Asunción. zoiloma@hotmail.com.

S Velázquez (S)

Pediatric Intensive Care, Pediatric Department, Central Hospital of the Social Welfare Institute, Asunción. zoiloma@hotmail.com.

F Martínez (F)

Pediatric Infectology, Pediatric Department, Central Hospital of the Social Welfare Institute, Asunción. zoiloma@hotmail.com.

V Lezcano (V)

Pediatric Infectology, Pediatric Department, Central Hospital of the Social Welfare Institute, Asunción, Paraguay. zoiloma@hotmail.com.

N Astigarraga (N)

Pediatric Cardiology, Pediatric Department, Central Hospital of the Social Welfare Institute, Asunción. zoiloma@hotmail.com.

C Ghezzi (C)

Pediatrics, Pediatric Department, Central Hospital of the Social Welfare Institute, Asunción. zoiloma@hotmail.com.

S Brizuela (S)

Pediatric Hematology, Pediatric Department, Central Hospital of the Social Welfare Institute, Asunción. zoiloma@hotmail.com.

G Samudio (G)

Pediatric Infectology, Pediatric Department, Central Hospital of the Social Welfare Institute, Asunción. zoiloma@hotmail.com.

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Classifications MeSH