Evidence of vertical transmission of SARS-CoV-2 and interstitial pneumonia in second-trimester twin stillbirth in asymptomatic woman. Case report and review of the literature.
Journal
American journal of obstetrics & gynecology MFM
ISSN: 2589-9333
Titre abrégé: Am J Obstet Gynecol MFM
Pays: United States
ID NLM: 101746609
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
11
10
2021
revised:
12
01
2022
accepted:
01
02
2022
pubmed:
9
2
2022
medline:
10
5
2022
entrez:
8
2
2022
Statut:
ppublish
Résumé
Data on the vertical transmission rate of COVID-19 in pregnancy are limited, although data reporting mother-fetal transmission in the second trimester of pregnancy are controversial. We described a case of second-trimester twin stillbirth in a woman with SARS-CoV-2 infection in which placental and fetal markers of infection were detected, despite the absence of respiratory syndrome. The patient developed clinical chorioamnionitis and spontaneously delivered 2 stillborn infants. Placental histology and immunohistochemistry demonstrated SARS-CoV-2 infection mostly within the syncytiotrophoblast, and fetal autopsy showed the development of interstitial pneumonia. Our findings demonstrated that in utero vertical transmission is possible in asymptomatic pregnant women with SARS-CoV-2 infection and that infection can lead to severe morbidity in the second trimester of pregnancy.
Identifiants
pubmed: 35131495
pii: S2589-9333(22)00029-5
doi: 10.1016/j.ajogmf.2022.100589
pmc: PMC8815276
pii:
doi:
Types de publication
Case Reports
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100589Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Références
J Clin Invest. 2020 Sep 1;130(9):4947-4953
pubmed: 32573498
Lancet Infect Dis. 2020 Oct;20(10):1135-1140
pubmed: 32526193
Eur J Clin Microbiol Infect Dis. 2020 Dec;39(12):2441-2445
pubmed: 32661809
Ultrasound Obstet Gynecol. 2021 Feb;57(2):242-247
pubmed: 32798244
JAMA. 2020 Jun 2;323(21):2198-2200
pubmed: 32352491
Viruses. 2020 Nov 15;12(11):
pubmed: 33203131
J Med Virol. 2021 Jul;93(7):4480-4487
pubmed: 33764543
CMAJ. 2021 Apr 19;193(16):E540-E548
pubmed: 33741725
Arch Dis Child Fetal Neonatal Ed. 2021 Jan;106(1):112-113
pubmed: 32586828
Arch Pathol Lab Med. 2021 May 1;145(5):517-528
pubmed: 33393592
Acta Obstet Gynecol Scand. 2020 May;99(5):565-568
pubmed: 32277845
Diagnostics (Basel). 2021 Jan 08;11(1):
pubmed: 33435547
Arch Pathol Lab Med. 2021 Aug 1;145(8):925-928
pubmed: 33878167