Linking a Trio of Molecular Features in Clear-Cell Renal Cell Carcinoma.
Journal
Cancer immunology research
ISSN: 2326-6074
Titre abrégé: Cancer Immunol Res
Pays: United States
ID NLM: 101614637
Informations de publication
Date de publication:
01 03 2022
01 03 2022
Historique:
pubmed:
9
2
2022
medline:
30
4
2022
entrez:
8
2
2022
Statut:
ppublish
Résumé
Clear-cell renal cell carcinoma exhibits unique molecular features, some of which are associated with the response to immunotherapy. However, the interactions between different genomic entities remains incompletely understood. In this issue, Zhou and colleagues show that PBRM1 inactivation is associated with increased expression of specific human endogenous retroviruses and identify HIF1/2A transcriptional activity as an important mediator of this interaction, helping uncover the interplay between some of the key molecular traits of this disease. See related article by Zhou et al., p. 285 (3).
Identifiants
pubmed: 35131809
pii: 2326-6066.CIR-22-0058
doi: 10.1158/2326-6066.CIR-22-0058
doi:
Substances chimiques
DNA-Binding Proteins
0
Nuclear Proteins
0
PBRM1 protein, human
0
Transcription Factors
0
Types de publication
Editorial
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
274Commentaires et corrections
Type : CommentOn
Informations de copyright
©2022 American Association for Cancer Research.