Presynaptic NMDARs on spinal nociceptor terminals state-dependently modulate synaptic transmission and pain.

Animals Brain-Derived Neurotrophic Factor / genetics Calcium / metabolism Chronic Pain / genetics Cyclic GMP-Dependent Protein Kinase Type I / genetics Ganglia, Spinal / cytology Inflammation Long-Term Potentiation Long-Term Synaptic Depression Mice Mice, Transgenic Nociceptors / metabolism Periaqueductal Gray / cytology Potassium Channels, Calcium-Activated / genetics Presynaptic Terminals / metabolism Receptors, N-Methyl-D-Aspartate / genetics Synaptic Transmission

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
07 02 2022
Historique:
received: 17 05 2020
accepted: 21 01 2022
entrez: 8 2 2022
pubmed: 9 2 2022
medline: 3 3 2022
Statut: epublish

Résumé

Postsynaptic NMDARs at spinal synapses are required for postsynaptic long-term potentiation and chronic pain. However, how presynaptic NMDARs (PreNMDARs) in spinal nociceptor terminals control presynaptic plasticity and pain hypersensitivity has remained unclear. Here we report that PreNMDARs in spinal nociceptor terminals modulate synaptic transmission in a nociceptive tone-dependent manner. PreNMDARs depresses presynaptic transmission in basal state, while paradoxically causing presynaptic potentiation upon injury. This state-dependent modulation is dependent on Ca

Identifiants

DOI: 10.1038/s41467-022-28429-y PMID: 35132099 PMC: PMC8821657
pubmed: 35132099
doi: 10.1038/s41467-022-28429-y
pii: 10.1038/s41467-022-28429-y
pmc: PMC8821657
doi:

Substances chimiques

Brain-Derived Neurotrophic Factor 0
Potassium Channels, Calcium-Activated 0
Receptors, N-Methyl-D-Aspartate 0
Cyclic GMP-Dependent Protein Kinase Type I EC 2.7.11.12
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

728

Informations de copyright

© 2022. The Author(s).

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Auteurs

Rou-Gang Xie (RG)

Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, 710032, Xi'an, China.
ORCID: 0000-0001-7644-1492

Wen-Guang Chu (WG)

Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, 710032, Xi'an, China.

Da-Lu Liu (DL)

Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, 710032, Xi'an, China.
Department of Radiation Medicine and Protection, Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, 710032, Xi'an, China.

Xu Wang (X)

Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, 710032, Xi'an, China.
Research Center for Resource Polypeptide Drugs & College of Life Sciences, Yanan University, 716000, Yanan, China.

Sui-Bin Ma (SB)

Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, 710032, Xi'an, China.

Fei Wang (F)

Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, 710032, Xi'an, China.

Fu-Dong Wang (FD)

Class 2015, The Fourth Squadron of the Fourth Regiment, School of Basic Medicine, Fourth Military Medical University, 710032, Xi'an, China.

Zhen Lin (Z)

Class 2013, The Fourth Squadron of the Second Regiment, School of Basic Medicine, Fourth Military Medical University, 710032, Xi'an, China.

Wen-Bin Wu (WB)

Class 2015, The Fourth Squadron of the Fourth Regiment, School of Basic Medicine, Fourth Military Medical University, 710032, Xi'an, China.

Na Lu (N)

Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, 710032, Xi'an, China.

Ying-Ying Liu (YY)

Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, 710032, Xi'an, China.

Wen-Juan Han (WJ)

Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, 710032, Xi'an, China.

Hui Zhang (H)

Department of Health Statistics, School of Preventive Medicine, Fourth Military Medical University, 710032, Xi'an, China.

Zhan-Tao Bai (ZT)

Research Center for Resource Polypeptide Drugs & College of Life Sciences, Yanan University, 716000, Yanan, China.

San-Jue Hu (SJ)

Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, 710032, Xi'an, China.

Hui-Ren Tao (HR)

Department of Spine Surgery, Shenzhen University General Hospital, 518055, Shenzhen, Guangdong, China.

Thomas Kuner (T)

Institute for Anatomy and Cell Biology, University of Heidelberg, Im Neuenheimer Feld 307, Heidelberg, 69120, Germany.
ORCID: 0000-0003-1896-9031

Xu Zhang (X)

Institute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 200031, Shanghai, China.

Rohini Kuner (R)

Pharmacology Institute, University of Heidelberg, Im Neuenheimer Feld 366, Heidelberg, 69120, Germany.
ORCID: 0000-0002-3333-9129

Sheng-Xi Wu (SX)

Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, 710032, Xi'an, China. shengxi@fmmu.edu.cn.
ORCID: 0000-0002-3210-9567

Ceng Luo (C)

Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, 710032, Xi'an, China. luoceng@fmmu.edu.cn.
ORCID: 0000-0003-3742-7713

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Presynaptic NMDARs on spinal nociceptor...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Facteurs de croissance nerveuse › Facteur neurotrophique dérivé du cerveau › Presynaptic NMDARs on spinal nociceptor...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Presynaptic NMDARs on spinal nociceptor...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Douleur chronique › Presynaptic NMDARs on spinal nociceptor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Cyclic Nucleotide-Regulated Protein Kinases › Cyclic GMP-Dependent Protein Kinases › Cyclic GMP-dependent protein kinase type I › Presynaptic NMDARs on spinal nociceptor...
questionsmedicales.fr › Système nerveux › Système nerveux périphérique › Nerfs périphériques › Nerfs spinaux › Racines des nerfs spinaux › Ganglions sensitifs des nerfs spinaux › Presynaptic NMDARs on spinal nociceptor...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Presynaptic NMDARs on spinal nociceptor...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Plasticité neuronale › Potentialisation à long terme › Presynaptic NMDARs on spinal nociceptor...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Plasticité neuronale › Dépression synaptique à long terme › Presynaptic NMDARs on spinal nociceptor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Presynaptic NMDARs on spinal nociceptor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Presynaptic NMDARs on spinal nociceptor...
questionsmedicales.fr › Cellules › Neurones › Neurones afférents › Cellules réceptrices sensorielles › Nocicepteurs › Presynaptic NMDARs on spinal nociceptor...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tronc cérébral › Mésencéphale › Pédoncule cérébral › Tegmentum du mésencéphale › Substance grise centrale du mésencéphale › Presynaptic NMDARs on spinal nociceptor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques calcium-dépendants › Presynaptic NMDARs on spinal nociceptor...
questionsmedicales.fr › Cellules › Neurones › Neurofibres › Axones › Terminaisons présynaptiques › Presynaptic NMDARs on spinal nociceptor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs au glutamate › Récepteurs ionotropes du glutamate › Récepteurs du N-méthyl-D-aspartate › Presynaptic NMDARs on spinal nociceptor...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › Presynaptic NMDARs on spinal nociceptor...