Rapid increase in Omicron infections in England during December 2021: REACT-1 study.

Adolescent Adult Aged COVID-19 / epidemiology COVID-19 Vaccines / administration & dosage Child Child, Preschool England / epidemiology Humans Immunization, Secondary Middle Aged Prevalence SARS-CoV-2 / isolation & purification

Journal

Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511

Informations de publication

Date de publication:
25 03 2022
Historique:
pubmed: 9 2 2022
medline: 6 4 2022
entrez: 8 2 2022
Statut: ppublish

Résumé

The unprecedented rise in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections during December 2021 was concurrent with rapid spread of the Omicron variant in England and globally. We analyzed the prevalence of SARS-CoV-2 and its dynamics in England from the end of November to mid-December 2021 among almost 100,000 participants in the REACT-1 study. Prevalence was high with rapid growth nationally and particularly in London during December 2021, with an increasing proportion of infections due to Omicron. We observed large decreases in swab positivity among mostly vaccinated older children (12 to 17 years) relative to unvaccinated younger children (5 to 11 years), and in adults who received a third (booster) vaccine dose versus two doses. Our results reinforce the importance of vaccination and booster campaigns, although additional measures have been needed to control the rapid growth of the Omicron variant.

Identifiants

DOI: 10.1126/science.abn8347 PMID: 35133177 PMC: PMC8939772
pubmed: 35133177
doi: 10.1126/science.abn8347
pmc: PMC8939772
doi:

Substances chimiques

COVID-19 Vaccines 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1406-1411

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_19012
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R015600/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S019669/1
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn

Références

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Lancet Respir Med. 2022 Apr;10(4):355-366
pubmed: 35085490
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pubmed: 34614326

Auteurs

Paul Elliott (P)

School of Public Health, Imperial College London, London, UK.
MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Imperial College Healthcare NHS Trust, London, UK.
National Institute for Health Research Imperial Biomedical Research Centre, London, UK.
Health Data Research (HDR) UK, Imperial College London, London, UK.
UK Dementia Research Institute, Imperial College London, London, UK.
ORCID: 0000-0002-7511-5684

Barbara Bodinier (B)

School of Public Health, Imperial College London, London, UK.
MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
ORCID: 0000-0002-0781-3624

Oliver Eales (O)

School of Public Health, Imperial College London, London, UK.
MRC Centre for Global infectious Disease Analysis and Jameel Institute, Imperial College London, London, UK.
ORCID: 0000-0002-8086-4495

Haowei Wang (H)

School of Public Health, Imperial College London, London, UK.
MRC Centre for Global infectious Disease Analysis and Jameel Institute, Imperial College London, London, UK.
ORCID: 0000-0003-4753-8783

David Haw (D)

School of Public Health, Imperial College London, London, UK.
MRC Centre for Global infectious Disease Analysis and Jameel Institute, Imperial College London, London, UK.
ORCID: 0000-0002-9228-0542

Joshua Elliott (J)

Imperial College Healthcare NHS Trust, London, UK.
Department of Infectious Disease, Imperial College London, London, UK.
ORCID: 0000-0002-9005-623X

Matthew Whitaker (M)

School of Public Health, Imperial College London, London, UK.
MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
ORCID: 0000-0003-1363-6537

Jakob Jonnerby (J)

School of Public Health, Imperial College London, London, UK.
National Heart and Lung Institute, Imperial College Healthcare NHS Trust, London, UK.

David Tang (D)

School of Public Health, Imperial College London, London, UK.
MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
ORCID: 0000-0002-6974-5663

Caroline E Walters (CE)

School of Public Health, Imperial College London, London, UK.
MRC Centre for Global infectious Disease Analysis and Jameel Institute, Imperial College London, London, UK.
ORCID: 0000-0003-1882-0886

Christina Atchison (C)

School of Public Health, Imperial College London, London, UK.
Imperial College Healthcare NHS Trust, London, UK.
ORCID: 0000-0001-8304-7389

Peter J Diggle (PJ)

Health Data Research (HDR) UK, Imperial College London, London, UK.
CHICAS, Lancaster Medical School, Lancaster University, Lancaster, UK.
ORCID: 0000-0003-3521-5020

Andrew J Page (AJ)

Quadram Institute, Norwich, UK.
ORCID: 0000-0001-6919-6062

Alexander J Trotter (AJ)

Quadram Institute, Norwich, UK.
ORCID: 0000-0001-5612-5310

Deborah Ashby (D)

School of Public Health, Imperial College London, London, UK.
ORCID: 0000-0003-3146-7466

Wendy Barclay (W)

Department of Infectious Disease, Imperial College London, London, UK.
ORCID: 0000-0002-3948-0895

Graham Taylor (G)

Department of Infectious Disease, Imperial College London, London, UK.
ORCID: 0000-0002-3773-2390

Helen Ward (H)

School of Public Health, Imperial College London, London, UK.
Imperial College Healthcare NHS Trust, London, UK.
National Institute for Health Research Imperial Biomedical Research Centre, London, UK.
MRC Centre for Global infectious Disease Analysis and Jameel Institute, Imperial College London, London, UK.
ORCID: 0000-0001-8238-5036

Ara Darzi (A)

Imperial College Healthcare NHS Trust, London, UK.
National Institute for Health Research Imperial Biomedical Research Centre, London, UK.
Institute of Global Health Innovation, Imperial College London, London, UK.
ORCID: 0000-0001-7815-7989

Graham S Cooke (GS)

Imperial College Healthcare NHS Trust, London, UK.
National Institute for Health Research Imperial Biomedical Research Centre, London, UK.
Department of Infectious Disease, Imperial College London, London, UK.
ORCID: 0000-0001-6475-5056

Marc Chadeau-Hyam (M)

School of Public Health, Imperial College London, London, UK.
MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
ORCID: 0000-0001-8341-5436

Christl A Donnelly (CA)

School of Public Health, Imperial College London, London, UK.
MRC Centre for Global infectious Disease Analysis and Jameel Institute, Imperial College London, London, UK.
Department of Statistics, University of Oxford, Oxford, UK.
ORCID: 0000-0002-0195-2463

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Rapid increase in Omicron infections in...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Rapid increase in Omicron infections in...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Rapid increase in Omicron infections in...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Rapid increase in Omicron infections in...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins antiviraux › Vaccins contre la COVID-19 › Rapid increase in Omicron infections in...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Rapid increase in Omicron infections in...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Rapid increase in Omicron infections in...
questionsmedicales.fr › Régions géographiques › Europe › Royaume-Uni › Angleterre › Rapid increase in Omicron infections in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Rapid increase in Omicron infections in...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Rappel de vaccin › Rapid increase in Omicron infections in...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Rapid increase in Omicron infections in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Morbidité › Prévalence › Rapid increase in Omicron infections in...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Rapid increase in Omicron infections in...