Cerebrospinal fluid kappa free light chains as biomarker in multiple sclerosis-from diagnosis to prediction of disease activity.
Clinically isolated syndrome
FLC index
Oligoclonal bands
Progression
Relapse
Journal
Wiener medizinische Wochenschrift (1946)
ISSN: 1563-258X
Titre abrégé: Wien Med Wochenschr
Pays: Austria
ID NLM: 8708475
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
received:
14
09
2021
accepted:
03
01
2022
pubmed:
9
2
2022
medline:
29
10
2022
entrez:
8
2
2022
Statut:
ppublish
Résumé
Multiple sclerosis (MS) is a chronic immune-mediated disorder of the central nervous system that shows a high interindividual heterogeneity, which frequently poses challenges regarding diagnosis and prediction of disease activity. In this context, evidence of intrathecal inflammation provides an important information and might be captured by kappa free light chains (κ-FLC) in the cerebrospinal fluid (CSF). In this review, we provide an overview on what is currently known about κ‑FLC, its historical development, the available assays and current evidence on its diagnostic and prognostic value in MS. Briefly, intrathecal κ‑FLC synthesis reaches similar diagnostic accuracy compared to the well-established CSF-restricted oligoclonal bands (OCB) to identify patients with MS, and recent studies even depict its value for prediction of early MS disease activity. Furthermore, detection of κ‑FLC has significant methodological advantages in comparison to OCB detection.
Identifiants
pubmed: 35133530
doi: 10.1007/s10354-022-00912-7
pii: 10.1007/s10354-022-00912-7
pmc: PMC9606042
doi:
Substances chimiques
Oligoclonal Bands
0
Immunoglobulin Light Chains
0
Immunoglobulin kappa-Chains
0
Biomarkers
0
Types de publication
Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
337-345Informations de copyright
© 2022. The Author(s).
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