Persistent B cell memory after SARS-CoV-2 vaccination is functional during breakthrough infections.
COVID-19
SARS-CoV-2
breakthrough infections
mRNA vaccine
memory B cells
mucosal immunity
salivary IgA
waning immunity
Journal
Cell host & microbe
ISSN: 1934-6069
Titre abrégé: Cell Host Microbe
Pays: United States
ID NLM: 101302316
Informations de publication
Date de publication:
09 03 2022
09 03 2022
Historique:
received:
17
11
2021
revised:
24
12
2021
accepted:
10
01
2022
pubmed:
9
2
2022
medline:
16
3
2022
entrez:
8
2
2022
Statut:
ppublish
Résumé
Breakthrough SARS-CoV-2 infections in fully vaccinated individuals are considered a consequence of waning immunity. Serum antibodies represent the most measurable outcome of vaccine-induced B cell memory. When antibodies decline, memory B cells are expected to persist and perform their function, preventing clinical disease. We investigated whether BNT162b2 mRNA vaccine induces durable and functional B cell memory in vivo against SARS-CoV-2 3, 6, and 9 months after the second dose in a cohort of health care workers (HCWs). While we observed physiological decline of SARS-CoV-2-specific antibodies, memory B cells persist and increase until 9 months after immunization. HCWs with breakthrough infections had no signs of waning immunity. In 3-4 days, memory B cells responded to SARS-CoV-2 infection by producing high levels of specific antibodies in the serum and anti-Spike IgA in the saliva. Antibodies to the viral nucleoprotein were produced with the slow kinetics typical of the response to a novel antigen.
Identifiants
pubmed: 35134333
pii: S1931-3128(22)00039-7
doi: 10.1016/j.chom.2022.01.003
pmc: PMC8820949
pii:
doi:
Substances chimiques
Antibodies, Viral
0
COVID-19 Vaccines
0
Vaccines, Synthetic
0
mRNA Vaccines
0
BNT162 Vaccine
N38TVC63NU
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
400-408.e4Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests All authors declare no competing interests.
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