Hair cortisol change at COVID-19 pandemic onset predicts burnout among health personnel.
Anxiety
Burnout
COVID-19
Cortisol
Depression
Health personnel
Post-traumatic stress disorder
Journal
Psychoneuroendocrinology
ISSN: 1873-3360
Titre abrégé: Psychoneuroendocrinology
Pays: England
ID NLM: 7612148
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
28
09
2021
revised:
23
11
2021
accepted:
21
12
2021
pubmed:
9
2
2022
medline:
4
3
2022
entrez:
8
2
2022
Statut:
ppublish
Résumé
The COVID-19 pandemic has put chronic pressure on worldwide healthcare systems. While the literature regarding the prevalence of psychological distress and associated risk factors among healthcare workers facing COVID-19 has exploded, biological variables have been mostly overlooked. 467 healthcare workers from Quebec, Canada, answered an electronic survey covering various risk factors and mental health outcomes three months after the onset of the COVID-19 pandemic. Of them, 372 (80%) provided a hair sample, providing a history of cortisol secretion for the three months preceding and following the pandemic's start. We used multivariable regression models and a receiver operating characteristic curve to study hair cortisol as a predictor of burnout and psychological health, together with individual, occupational, social, and organizational factors. As expected, hair cortisol levels increased after the start of the pandemic, with a median relative change of 29% (IQR = 3-59%, p < 0.0001). There was a significant association between burnout status and change in cortisol, with participants in the second quarter of change having lower odds of burnout. No association was found between cortisol change and post-traumatic stress disorder, anxiety, and depression symptoms. Adding cortisol to individual-occupational-socio-organizational factors noticeably enhanced our burnout logistic regression model's predictability. Change in hair cortisol levels predicted burnout at three months in health personnel at the onset of the COVID-19 pandemic. This non-invasive biological marker of the stress response could be used in further clinical or research initiatives to screen high-risk individuals to prevent and control burnout in health personnel facing an important stressor.
Sections du résumé
BACKGROUND
The COVID-19 pandemic has put chronic pressure on worldwide healthcare systems. While the literature regarding the prevalence of psychological distress and associated risk factors among healthcare workers facing COVID-19 has exploded, biological variables have been mostly overlooked.
METHODS
467 healthcare workers from Quebec, Canada, answered an electronic survey covering various risk factors and mental health outcomes three months after the onset of the COVID-19 pandemic. Of them, 372 (80%) provided a hair sample, providing a history of cortisol secretion for the three months preceding and following the pandemic's start. We used multivariable regression models and a receiver operating characteristic curve to study hair cortisol as a predictor of burnout and psychological health, together with individual, occupational, social, and organizational factors.
RESULTS
As expected, hair cortisol levels increased after the start of the pandemic, with a median relative change of 29% (IQR = 3-59%, p < 0.0001). There was a significant association between burnout status and change in cortisol, with participants in the second quarter of change having lower odds of burnout. No association was found between cortisol change and post-traumatic stress disorder, anxiety, and depression symptoms. Adding cortisol to individual-occupational-socio-organizational factors noticeably enhanced our burnout logistic regression model's predictability.
CONCLUSION
Change in hair cortisol levels predicted burnout at three months in health personnel at the onset of the COVID-19 pandemic. This non-invasive biological marker of the stress response could be used in further clinical or research initiatives to screen high-risk individuals to prevent and control burnout in health personnel facing an important stressor.
Identifiants
pubmed: 35134663
pii: S0306-4530(21)00519-9
doi: 10.1016/j.psyneuen.2021.105645
pmc: PMC8697418
pii:
doi:
Substances chimiques
Biomarkers
0
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
105645Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.
Références
J Occup Health. 2021 Jan;63(1):e12189
pubmed: 33426766
Stress. 2012 Nov;15(6):578-88
pubmed: 22356099
J Psychiatr Res. 2017 Jan;84:184-190
pubmed: 27744230
J Gen Intern Med. 2009 Dec;24(12):1318-21
pubmed: 19802645
J Psychosom Res. 2002 Feb;52(2):69-77
pubmed: 11832252
Arch Gen Psychiatry. 2009 Jun;66(6):617-26
pubmed: 19487626
Psychoneuroendocrinology. 2013 Aug;38(8):1220-35
pubmed: 23253896
Psychoneuroendocrinology. 2012 May;37(5):589-601
pubmed: 21974976
Acta Psychiatr Scand. 2018 Mar;137(3):216-230
pubmed: 29397570
Br J Psychiatry. 2007 Nov;191:387-92
pubmed: 17978317
Endocrinology. 2012 Sep;153(9):4120-7
pubmed: 22778226
Curr Top Behav Neurosci. 2014;18:191-216
pubmed: 24659553
J Psychiatr Res. 2020 Oct;129:198-205
pubmed: 32763586
Brain Sci. 2021 Mar 09;11(3):
pubmed: 33803413
Psychoneuroendocrinology. 2016 Aug;70:58-62
pubmed: 27164223
Palliat Support Care. 2018 Jun;16(3):286-297
pubmed: 28434435
J Affect Disord. 2020 Apr 15;267:307-314
pubmed: 32217231
Neuropsychopharmacology. 2000 Nov;23(5):477-501
pubmed: 11027914
J Affect Disord. 2020 Oct 1;275:210-215
pubmed: 32734910
JAMA. 2015 Sep 8;314(10):1063-4
pubmed: 26348755
Psychoneuroendocrinology. 2015 Jan;51:365-70
pubmed: 25462908
Biol Psychiatry. 2012 Jul 1;72(1):65-9
pubmed: 22305287
Psychoneuroendocrinology. 2019 Mar;101:246-252
pubmed: 30472466
Curr Pharm Biotechnol. 2017;18(3):194-203
pubmed: 28240172
Eur J Endocrinol. 2015 Oct;173(4):M1-10
pubmed: 25924811
Gen Hosp Psychiatry. 2020 Nov-Dec;67:144-145
pubmed: 32381270
J Affect Disord. 2013 May;147(1-3):171-9
pubmed: 23218249
Int J Environ Res Public Health. 2020 Jul 20;17(14):
pubmed: 32698320
Int J Bipolar Disord. 2020 Mar 5;8(1):15
pubmed: 32133545
Brain Behav Immun. 2020 Aug;88:901-907
pubmed: 32437915
J Trauma Stress. 2015 Dec;28(6):489-98
pubmed: 26606250
BJPsych Open. 2020 Apr 23;6(3):e41
pubmed: 32321622
Psychoneuroendocrinology. 2021 Feb;124:105098
pubmed: 33310696
BMC Clin Pathol. 2011 Oct 25;11:12
pubmed: 22026917
Acta Psychiatr Scand. 1983 Jun;67(6):361-70
pubmed: 6880820
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Aug 1;32(6):1459-65
pubmed: 18541357
PLoS One. 2020 Sep 3;15(9):e0238217
pubmed: 32881887
Front Psychiatry. 2014 Jul 11;5:80
pubmed: 25071612
Int J Occup Med Environ Health. 2013 Jun;26(3):401-12
pubmed: 24018996
Psychoneuroendocrinology. 2018 Jun;92:57-65
pubmed: 29627713
Clin Biochem. 2019 Jan;63:1-9
pubmed: 30261181
Front Psychol. 2021 Mar 18;12:621853
pubmed: 33815205
Biol Psychiatry. 2013 Nov 1;74(9):639-46
pubmed: 23623187
Int Arch Occup Environ Health. 2020 Aug;93(6):779-788
pubmed: 32170362
Psychoneuroendocrinology. 2005 Oct;30(9):846-56
pubmed: 15961250
Fertil Steril. 2018 Jun;109(6):952-963
pubmed: 29935653
Psychoneuroendocrinology. 2021 Jun;128:105213
pubmed: 33845387
J Psychiatr Res. 2021 Aug;140:474-487
pubmed: 34153902
Neurosci Biobehav Rev. 2020 Jul;114:232-270
pubmed: 32088345
Brain Behav Immun. 2012 Oct;26(7):1019-29
pubmed: 22366690
Acad Med. 2014 Mar;89(3):443-51
pubmed: 24448053
Psychother Psychosom. 2020;89(4):242-250
pubmed: 32272480
PLoS One. 2014 Dec 12;9(12):e114987
pubmed: 25501716
BMC Emerg Med. 2020 Oct 15;20(1):82
pubmed: 33059583
Am J Respir Crit Care Med. 2007 Apr 1;175(7):698-704
pubmed: 17110646
Psychol Assess. 2016 Nov;28(11):1392-1403
pubmed: 26751087
PLoS One. 2016 Oct 10;11(10):e0161645
pubmed: 27723815
Nord J Psychiatry. 2017 Jan;71(1):12-19
pubmed: 27564242
Psychiatry Res. 2011 Apr 30;186(2-3):310-4
pubmed: 20889215
BMC Public Health. 2020 Dec 7;20(1):1885
pubmed: 33287794
BMB Rep. 2015 Apr;48(4):209-16
pubmed: 25560699
Brain Behav Immun. 2020 Aug;88:559-565
pubmed: 32330593
Front Psychiatry. 2021 Jan 28;11:589545
pubmed: 33584364
Clin Invest Med. 2007;30(5):E183-91
pubmed: 17892760
Psychoneuroendocrinology. 2021 Jul;129:105245
pubmed: 33951563
Psychol Assess. 2016 Nov;28(11):1379-1391
pubmed: 26653052
Ann Intensive Care. 2020 Aug 8;10(1):110
pubmed: 32770449
Psychoneuroendocrinology. 2009 Jan;34(1):32-7
pubmed: 18947933
Neuropsychiatr Dis Treat. 2010 Sep 07;6:393-400
pubmed: 20856603
Front Psychiatry. 2021 Jul 08;12:668278
pubmed: 34305675
Psychoneuroendocrinology. 2017 Mar;77:261-274
pubmed: 28135674