Potassium responses to sodium zirconium cyclosilicate in hyperkalemic hemodialysis patients: post-hoc analysis of DIALIZE.
Chronic kidney disease
Hemodialysis
Hyperkalemia
Potassium
Sodium zirconium cyclosilicate
Journal
BMC nephrology
ISSN: 1471-2369
Titre abrégé: BMC Nephrol
Pays: England
ID NLM: 100967793
Informations de publication
Date de publication:
08 02 2022
08 02 2022
Historique:
received:
23
03
2021
accepted:
14
09
2021
entrez:
9
2
2022
pubmed:
10
2
2022
medline:
11
3
2022
Statut:
epublish
Résumé
Sodium zirconium cyclosilicate (SZC) is an effective and well-tolerated treatment for hyperkalemia in maintenance hemodialysis patients. In post-hoc analyses of the phase 3b DIALIZE study, we examined the spectrum of potassium responses to SZC. Post-hoc analyses with SZC and placebo included: the number of long interdialytic interval (LIDI) visits during the 4-week evaluation period where patients attained pre-dialysis serum potassium (sK A greater proportion of patients achieved the ranges of pre-dialysis sK These analyses expand our knowledge of the spectrum of potassium responses with SZC in hyperkalemic hemodialysis patients. NCT03303521 .
Sections du résumé
BACKGROUND
Sodium zirconium cyclosilicate (SZC) is an effective and well-tolerated treatment for hyperkalemia in maintenance hemodialysis patients. In post-hoc analyses of the phase 3b DIALIZE study, we examined the spectrum of potassium responses to SZC.
METHODS
Post-hoc analyses with SZC and placebo included: the number of long interdialytic interval (LIDI) visits during the 4-week evaluation period where patients attained pre-dialysis serum potassium (sK
RESULTS
A greater proportion of patients achieved the ranges of pre-dialysis sK
CONCLUSIONS
These analyses expand our knowledge of the spectrum of potassium responses with SZC in hyperkalemic hemodialysis patients.
TRIAL REGISTRATION
NCT03303521 .
Identifiants
pubmed: 35135481
doi: 10.1186/s12882-021-02569-7
pii: 10.1186/s12882-021-02569-7
pmc: PMC8826669
doi:
Substances chimiques
Dialysis Solutions
0
Ion Exchange Resins
0
Silicates
0
sodium zirconium cyclosilicate
D652ZWF066
Potassium
RWP5GA015D
Banques de données
ClinicalTrials.gov
['NCT03303521']
Types de publication
Clinical Trial, Phase III
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
59Informations de copyright
© 2022. The Author(s).
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