Metabolite and lipoprotein profiles reveal sex-related oxidative stress imbalance in de novo drug-naive Parkinson's disease patients.


Journal

NPJ Parkinson's disease
ISSN: 2373-8057
Titre abrégé: NPJ Parkinsons Dis
Pays: United States
ID NLM: 101675390

Informations de publication

Date de publication:
08 Feb 2022
Historique:
received: 21 04 2021
accepted: 16 12 2021
entrez: 9 2 2022
pubmed: 10 2 2022
medline: 10 2 2022
Statut: epublish

Résumé

Parkinson's disease (PD) is the neurological disorder showing the greatest rise in prevalence from 1990 to 2016. Despite clinical definition criteria and a tremendous effort to develop objective biomarkers, precise diagnosis of PD is still unavailable at early stage. In recent years, an increasing number of studies have used omic methods to unveil the molecular basis of PD, providing a detailed characterization of potentially pathological alterations in various biological specimens. Metabolomics could provide useful insights to deepen our knowledge of PD aetiopathogenesis, to identify signatures that distinguish groups of patients and uncover responsive biomarkers of PD that may be significant in early detection and in tracking the disease progression and drug treatment efficacy. The present work is the first large metabolomic study based on nuclear magnetic resonance (NMR) with an independent validation cohort aiming at the serum characterization of de novo drug-naive PD patients. Here, NMR is applied to sera from large training and independent validation cohorts of German subjects. Multivariate and univariate approaches are used to infer metabolic differences that characterize the metabolite and the lipoprotein profiles of newly diagnosed de novo drug-naive PD patients also in relation to the biological sex of the subjects in the study, evidencing a more pronounced fingerprint of the pathology in male patients. The presence of a validation cohort allowed us to confirm altered levels of acetone and cholesterol in male PD patients. By comparing the metabolites and lipoproteins levels among de novo drug-naive PD patients, age- and sex-matched healthy controls, and a group of advanced PD patients, we detected several descriptors of stronger oxidative stress.

Identifiants

pubmed: 35136088
doi: 10.1038/s41531-021-00274-8
pii: 10.1038/s41531-021-00274-8
pmc: PMC8826921
doi:

Types de publication

Journal Article

Langues

eng

Pagination

14

Subventions

Organisme : EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020)
ID : 634821
Organisme : EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Societal Challenges | H2020 Health (H2020 Societal Challenges - Health, Demographic Change and Well-being)
ID : 634821

Investigateurs

Alessandra Dal Molin (AD)
Anna Bartoletti-Stella (A)
Anna Gabellini (A)
Astrid Daniela Adarmes-Gómez (AD)
Cesa Lorella Maria Scaglione (CLM)
Christine Nardini (C)
Cilea Rosaria (C)
Claudia Boninsegna (C)
Claudia Sala (C)
Cristina Giuliani (C)
Cristina Tejera-Parrado (C)
Daniel Macias (D)
Dolores Buiza-Rueda (D)
Dylan Williams (D)
Elisa Zago (E)
Federica Provini (F)
Francesca Magrinelli (F)
Francesco Mignani (F)
Francesco Ravaioli (F)
Franco Valzania (F)
Friederike Sixel-Döring (F)
Giacomo Mengozzi (G)
Giovanna Calandra-Buonaura (G)
Giovanna Maria Dimitri (GM)
Giovanni Fabbri (G)
Henry Houlden (H)
Ismael Huertas (I)
Ivan Doykov (I)
Jenny Hällqvist (J)
Juan Francisco Martín Rodríguez (JFM)
Juulia Jylhävä (J)
Kailash P Bhatia (KP)
Kevin Mills (K)
Luca Baldelli (L)
Luciano Xumerle (L)
Luisa Sambati (L)
Maddalena Milazzo (M)
Marcella Broli (M)
Maria Giovanna Maturo (MG)
Maria Teresa Periñán-Tocino (MT)
Mario Carriòn-Claro (M)
Marta Bonilla-Toribio (M)
Massimo Delledonne (M)
Miguel A Labrador-Espinosa (MA)
Nancy L Pedersen (NL)
Pablo Mir (P)
Patrizia De Massis (P)
Pietro Cortelli (P)
Pietro Guaraldi (P)
Pietro Liò (P)
Pilar Gómez-Garre (P)
Robert Clayton (R)
Rocio Escuela-Martin (R)
Rosario Vigo Ortega (RV)
Sabina Capellari (S)
Sara Hägg (S)
Sebastian R Schreglmann (SR)
Silvia De Luca (S)
Simeon Spasov (S)
Stefania Alessandra Nassetti (SA)
Stefania Macrì (S)
Tiago Azevedo (T)
Wendy Heywood (W)

Informations de copyright

© 2022. The Author(s).

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Auteurs

Gaia Meoni (G)

Magnetic Resonance Center (CERM) and Department of Chemistry "Ugo Schiff", University of Florence, Sesto Fiorentino, Florence, Italy.

Leonardo Tenori (L)

Magnetic Resonance Center (CERM) and Department of Chemistry "Ugo Schiff", University of Florence, Sesto Fiorentino, Florence, Italy.
Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine (C.I.R.M.M.P.), Sesto Fiorentino, Florence, Italy.

Sebastian Schade (S)

Department of Clinical Neurophysiology, University Medical Center Goettingen, Goettingen, Germany.

Cristina Licari (C)

Magnetic Resonance Center (CERM) and Department of Chemistry "Ugo Schiff", University of Florence, Sesto Fiorentino, Florence, Italy.

Chiara Pirazzini (C)

IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.

Maria Giulia Bacalini (MG)

IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.

Paolo Garagnani (P)

Department of Experimental, Diagnostic, and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.

Paola Turano (P)

Magnetic Resonance Center (CERM) and Department of Chemistry "Ugo Schiff", University of Florence, Sesto Fiorentino, Florence, Italy.
Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine (C.I.R.M.M.P.), Sesto Fiorentino, Florence, Italy.

Claudia Trenkwalder (C)

University Medical Center Goettingen, Department of Neurology and Paracelsus-Elena-Klinik, Kassel, Germany.

Claudio Franceschi (C)

Department of Experimental, Diagnostic, and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy. claudio.franceschi@unibo.it.
Laboratory of Systems Medicine of Healthy Aging and Department of Applied Mathematics, Lobachevsky University, Nizhny Novgorod, Russia. claudio.franceschi@unibo.it.

Brit Mollenhauer (B)

University Medical Center Goettingen, Department of Neurology and Paracelsus-Elena-Klinik, Kassel, Germany. brit.mollenhauer@med.uni-goettingen.de.

Claudio Luchinat (C)

Magnetic Resonance Center (CERM) and Department of Chemistry "Ugo Schiff", University of Florence, Sesto Fiorentino, Florence, Italy. luchinat@cerm.unifi.it.
Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine (C.I.R.M.M.P.), Sesto Fiorentino, Florence, Italy. luchinat@cerm.unifi.it.

Classifications MeSH