Dyspepsia and Gut Microbiota in Female Patients with Postcholecystectomy Syndrome.
female patients
gut microbiota imbalance
postcholecystectomy syndrome
Journal
International journal of women's health
ISSN: 1179-1411
Titre abrégé: Int J Womens Health
Pays: New Zealand
ID NLM: 101531698
Informations de publication
Date de publication:
2022
2022
Historique:
received:
13
10
2021
accepted:
06
01
2022
entrez:
9
2
2022
pubmed:
10
2
2022
medline:
10
2
2022
Statut:
epublish
Résumé
Gallstone disease (GSD) represents one of the most frequent digestive disorders, highly reported in female gender. The purpose of the study was to explore the clinical and gut microbiota particularities of female patients with postcholecystectomy syndrome (PCS) and the possible relationship between gut dysbiosis (DB) and abdominal complaints. In total, 129 female participants: 104 outpatients divided into two equal groups, 52 PCS (+), 52 PCS (-) and 25 healthy controls were consecutively enrolled in this observational study. Patients underwent clinical examination with assessment of pain, bloating, transit disturbances, abdominal ultrasound/computer tomography/magnetic resonance imaging/endoscopic retrograde cholangiopancreatography, upper and lower digestive endoscopies. Laboratory work-ups and stool microbiology assessments were performed for all study participants (patients and controls). Stool microorganisms were identified by matrix-assisted laser desorption ionization - time-of-flight- mass spectrometry and in patients with DB also by next-generation sequencing. Older age, complicated gallstones disease, associated conditions like diabetes mellitus/impaired glucose tolerance and irritable bowel syndrome were significantly present in PCS (+) group, as well as sedentary lifestyle and diets characterized by a low fiber intake (p<0.0001). PCS (+) patients displayed significant differences related to the incidence and severity of overall gut microbiota DB, decreased H index of biodiversity and the unbalanced Firmicutes/Bacteroidetes (F/B) ratios by comparison to the PCS (-) group (p<0.0001). Strong positive correlations of the severity of overall DB with bloating and the intestinal habit disorders, as well as of F/B ratios to all abdominal symptoms were noted. PCS in female patients was associated with older age, sedentary lifestyle, specific dietary habits, history of complicated gallstone disease, diabetes mellitus/impaired glucose tolerance and irritable bowel syndrome, as well as gut microbiota particularities. Overall DB and unbalanced F/B ratios were strongly correlated to abdominal complaints.
Sections du résumé
BACKGROUND
BACKGROUND
Gallstone disease (GSD) represents one of the most frequent digestive disorders, highly reported in female gender. The purpose of the study was to explore the clinical and gut microbiota particularities of female patients with postcholecystectomy syndrome (PCS) and the possible relationship between gut dysbiosis (DB) and abdominal complaints.
PATIENTS AND METHODS
METHODS
In total, 129 female participants: 104 outpatients divided into two equal groups, 52 PCS (+), 52 PCS (-) and 25 healthy controls were consecutively enrolled in this observational study. Patients underwent clinical examination with assessment of pain, bloating, transit disturbances, abdominal ultrasound/computer tomography/magnetic resonance imaging/endoscopic retrograde cholangiopancreatography, upper and lower digestive endoscopies. Laboratory work-ups and stool microbiology assessments were performed for all study participants (patients and controls). Stool microorganisms were identified by matrix-assisted laser desorption ionization - time-of-flight- mass spectrometry and in patients with DB also by next-generation sequencing.
RESULTS
RESULTS
Older age, complicated gallstones disease, associated conditions like diabetes mellitus/impaired glucose tolerance and irritable bowel syndrome were significantly present in PCS (+) group, as well as sedentary lifestyle and diets characterized by a low fiber intake (p<0.0001). PCS (+) patients displayed significant differences related to the incidence and severity of overall gut microbiota DB, decreased H index of biodiversity and the unbalanced Firmicutes/Bacteroidetes (F/B) ratios by comparison to the PCS (-) group (p<0.0001). Strong positive correlations of the severity of overall DB with bloating and the intestinal habit disorders, as well as of F/B ratios to all abdominal symptoms were noted.
CONCLUSION
CONCLUSIONS
PCS in female patients was associated with older age, sedentary lifestyle, specific dietary habits, history of complicated gallstone disease, diabetes mellitus/impaired glucose tolerance and irritable bowel syndrome, as well as gut microbiota particularities. Overall DB and unbalanced F/B ratios were strongly correlated to abdominal complaints.
Identifiants
pubmed: 35136356
doi: 10.2147/IJWH.S342882
pii: 342882
pmc: PMC8816732
doi:
Types de publication
Journal Article
Langues
eng
Pagination
41-56Informations de copyright
© 2022 Georgescu et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest in this work.
Références
J Gastroenterol Hepatol. 2017 Jan;32(1):28-38
pubmed: 27300149
Microbiome. 2021 Feb 6;9(1):39
pubmed: 33549144
BMC Gastroenterol. 2020 Mar 6;20(1):59
pubmed: 32143645
J Clin Transl Hepatol. 2015 Mar;3(1):78-84
pubmed: 26357637
World J Gastroenterol. 2016 Feb 21;22(7):2219-41
pubmed: 26900286
Best Pract Res Clin Gastroenterol. 2006;20(6):1017-29
pubmed: 17127185
Front Pharmacol. 2018 Sep 25;9:1082
pubmed: 30319417
Rom J Morphol Embryol. 2019;60(1):205-210
pubmed: 31263846
Gastroenterology. 2006 Apr;130(5):1377-90
pubmed: 16678553
Int J Surg. 2017 Mar;39:119-126
pubmed: 28104466
J Gastrointestin Liver Dis. 2009 Mar;18(1):67-71
pubmed: 19337637
J Emerg Med. 2010 Oct;39(4):406-10
pubmed: 18722735
Medicina (Kaunas). 2019 Dec 16;55(12):
pubmed: 31888137
J Visc Surg. 2013 Sep;150(4):229-35
pubmed: 23916848
Gastroenterology. 2019 Jul;157(1):97-108
pubmed: 30940523
Environ Microbiol Rep. 2015 Dec;7(6):874-80
pubmed: 26149537
Clin Res Hepatol Gastroenterol. 2018 Apr;42(2):110-117
pubmed: 29102544
BMC Gastroenterol. 2017 Jun 9;17(1):74
pubmed: 28599622
Circulation. 2004 Jul 13;110(2):227-39
pubmed: 15249516
Front Microbiol. 2018 Jun 25;9:1402
pubmed: 29988510
Int J Surg. 2010;8(1):15-7
pubmed: 19857610
Med Sci Monit. 2019 Sep 29;25:7312-7320
pubmed: 31563920
Ann Hepatobiliary Pancreat Surg. 2018 Feb;22(1):52-57
pubmed: 29536056
Front Microbiol. 2018 Jan 30;9:61
pubmed: 29441049
Microbiome. 2017 Feb 1;5(1):14
pubmed: 28143587
J Clin Med. 2019 Jan 11;8(1):
pubmed: 30641967
BMC Microbiol. 2018 Aug 29;18(1):92
pubmed: 30157754
World J Gastrointest Surg. 2017 May 27;9(5):118-126
pubmed: 28603584
Gut Liver. 2012 Apr;6(2):172-87
pubmed: 22570746
Hepatology. 2018 Jan;67(1):328-357
pubmed: 28714183
World J Gastroenterol. 2012 Mar 28;18(12):1365-72
pubmed: 22493550
Trop Gastroenterol. 2004 Apr-Jun;25(2):65-8
pubmed: 15471318
Am J Physiol Gastrointest Liver Physiol. 2017 Jan 1;312(1):G52-G62
pubmed: 27881403
Nature. 2015 Dec 10;528(7581):262-266
pubmed: 26633628
Diabetes Care. 2014 Jan;37 Suppl 1:S81-90
pubmed: 24357215
Front Cell Infect Microbiol. 2020 Nov 24;10:572912
pubmed: 33330122
J Cell Mol Med. 2019 Apr;23(4):2343-2350
pubmed: 30712327
Biomedicines. 2020 Nov 10;8(11):
pubmed: 33182693
Curr Opin Gastroenterol. 2018 Mar;34(2):71-80
pubmed: 29283909
Surg Endosc. 2013 Mar;27(3):709-18
pubmed: 23052498
Curr Opin Gastroenterol. 2013 Jan;29(1):49-54
pubmed: 23041677
Mass Spectrom Rev. 2013 May-Jun;32(3):188-217
pubmed: 22996584
BMC Genomics. 2013 Oct 01;14:669
pubmed: 24083370
Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14691-6
pubmed: 20679230
Postgrad Med. 2017 Nov;129(8):872-888
pubmed: 28936910
J Minim Access Surg. 2018 Jul-Sep;14(3):202-207
pubmed: 29067945
Surgeon. 2019 Feb;17(1):33-42
pubmed: 29730174
J Fam Pract. 2011 Oct;60(10):632c-d
pubmed: 21977493
Minerva Chir. 1997 Dec;52(12):1435-9
pubmed: 9557456
Nutr Hosp. 2013 May-Jun;28(3):553-7
pubmed: 23848071
Nature. 2011 May 12;473(7346):174-80
pubmed: 21508958
World J Gastroenterol. 2014 Nov 21;20(43):16079-94
pubmed: 25473159
Mediators Inflamm. 2018 Dec 9;2018:2037838
pubmed: 30622429
Front Oncol. 2020 Aug 12;10:1418
pubmed: 32903396
Front Genet. 2015 Jun 23;6:219
pubmed: 26157455
Am J Gastroenterol. 2005 Nov;100(11):2540-50
pubmed: 16279912