Physiological effects and subjective tolerability of prone positioning in COVID-19 and healthy hypoxic challenge.
Journal
ERJ open research
ISSN: 2312-0541
Titre abrégé: ERJ Open Res
Pays: England
ID NLM: 101671641
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
25
08
2021
accepted:
26
10
2021
entrez:
9
2
2022
pubmed:
10
2
2022
medline:
10
2
2022
Statut:
epublish
Résumé
Prone positioning has a beneficial role in coronavirus disease 2019 (COVID-19) patients receiving ventilation but lacks evidence in awake non-ventilated patients, with most studies being retrospective, lacking control populations and information on subjective tolerability. We conducted a prospective, single-centre study of prone positioning in awake non-ventilated patients with COVID-19 and non-COVID-19 pneumonia. The primary outcome was change in peripheral oxygenation in prone 238 hospitalised patients with pneumonia were screened; 55 were eligible with 25 COVID-19 patients and three non-COVID-19 patients agreeing to undergo proning - the latter insufficient for further analysis. 10 healthy control volunteers underwent hypoxic challenge. Patients with COVID-19 had a median age of 64 years (interquartile range 53-75). Proning led to an increase in oxygen saturation measured by pulse oximetry ( Identification of suitable patients with COVID-19 requiring oxygen supplementation from general ward environments for awake proning is challenging. Prone positioning leads to a small increase in
Sections du résumé
BACKGROUND
BACKGROUND
Prone positioning has a beneficial role in coronavirus disease 2019 (COVID-19) patients receiving ventilation but lacks evidence in awake non-ventilated patients, with most studies being retrospective, lacking control populations and information on subjective tolerability.
METHODS
METHODS
We conducted a prospective, single-centre study of prone positioning in awake non-ventilated patients with COVID-19 and non-COVID-19 pneumonia. The primary outcome was change in peripheral oxygenation in prone
RESULTS
RESULTS
238 hospitalised patients with pneumonia were screened; 55 were eligible with 25 COVID-19 patients and three non-COVID-19 patients agreeing to undergo proning - the latter insufficient for further analysis. 10 healthy control volunteers underwent hypoxic challenge. Patients with COVID-19 had a median age of 64 years (interquartile range 53-75). Proning led to an increase in oxygen saturation measured by pulse oximetry (
CONCLUSION
CONCLUSIONS
Identification of suitable patients with COVID-19 requiring oxygen supplementation from general ward environments for awake proning is challenging. Prone positioning leads to a small increase in
Identifiants
pubmed: 35136823
doi: 10.1183/23120541.00524-2021
pii: 00524-2021
pmc: PMC8591389
pii:
doi:
Types de publication
Journal Article
Langues
eng
Informations de copyright
Copyright ©The authors 2022.
Déclaration de conflit d'intérêts
Conflict of interest: None declared.
Références
N Engl J Med. 2013 Jun 6;368(23):2159-68
pubmed: 23688302
Chest. 2021 Jul;160(1):85-88
pubmed: 33516704
Thorax. 2020 Oct;75(10):833-834
pubmed: 32546571
J Crit Care. 2015 Dec;30(6):1390-4
pubmed: 26271685
Acta Anaesthesiol Scand. 2003 Apr;47(4):416-8
pubmed: 12694139
BMJ. 2020 May 22;369:m1985
pubmed: 32444460
Transplant Proc. 2012 Sep;44(7):2016-21
pubmed: 22974896
Thorax. 2009 Jun;64(6):532-4
pubmed: 19318347
JAMA. 2020 Aug 25;324(8):782-793
pubmed: 32648899
Eur Respir Rev. 2014 Jun;23(132):249-57
pubmed: 24881080
JAMA. 2020 Jun 9;323(22):2336-2338
pubmed: 32412581
Ann Am Thorac Soc. 2021 Aug;18(8):1424-1426
pubmed: 33596394
J Infect. 2020 Aug;81(2):282-288
pubmed: 32479771
Can J Anaesth. 2021 Jan;68(1):64-70
pubmed: 32803468