Homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium.
epithelium
immunology
infectious disease
inflammation
innate immunity
interferon
intestine
microbiology
microbiota
mouse
rotavirus
viruses
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
09 02 2022
09 02 2022
Historique:
received:
21
09
2021
accepted:
04
02
2022
pubmed:
10
2
2022
medline:
25
2
2022
entrez:
9
2
2022
Statut:
epublish
Résumé
Interferon-lambda (IFN-λ) protects intestinal epithelial cells (IECs) from enteric viruses by inducing expression of antiviral IFN-stimulated genes (ISGs). Here, we find that bacterial microbiota stimulate a homeostatic ISG signature in the intestine of specific pathogen-free mice. This homeostatic ISG expression is restricted to IECs, depends on IEC-intrinsic expression of IFN-λ receptor (
Identifiants
pubmed: 35137688
doi: 10.7554/eLife.74072
pii: 74072
pmc: PMC8853662
doi:
pii:
Substances chimiques
IFNLR1 protein, mouse
0
Receptors, Interferon
0
Banques de données
GEO
['GSE92332']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI141478
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI141716
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI139314
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007472
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI130055
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA091842
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM071338
Pays : United States
Informations de copyright
© 2022, Van Winkle et al.
Déclaration de conflit d'intérêts
JV, SP, EK, MW, HI, CD, RR, DC, AW, LL, MA, SL, MB, TN No competing interests declared
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