Ribonucleotide reductase, a novel drug target for gonorrhea.
Allosteric Regulation
Animals
Anti-Bacterial Agents
/ pharmacology
Deoxyadenine Nucleotides
/ metabolism
Disease Models, Animal
Drug Resistance, Bacterial
/ drug effects
Escherichia coli
/ drug effects
Female
Gonorrhea
/ drug therapy
Humans
Mice
Mice, Inbred BALB C
Microbial Sensitivity Tests
/ methods
Neisseria gonorrhoeae
/ drug effects
Pyridines
/ pharmacology
Ribonucleotide Reductases
/ metabolism
2-pyridone
gonorrhea
infectious disease
microbiology
multidrug resistance
neisseria gonorrhoeae
ribonucleotide reductase
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
09 02 2022
09 02 2022
Historique:
received:
11
02
2021
accepted:
08
02
2022
pubmed:
10
2
2022
medline:
18
3
2022
entrez:
9
2
2022
Statut:
epublish
Résumé
Antibiotic-resistant
Identifiants
pubmed: 35137690
doi: 10.7554/eLife.67447
pii: 67447
pmc: PMC8865847
doi:
pii:
Substances chimiques
Anti-Bacterial Agents
0
Deoxyadenine Nucleotides
0
Pyridines
0
2,4-dihydroxypyridine
626-03-9
Ribonucleotide Reductases
EC 1.17.4.-
2'-deoxyadenosine triphosphate
K8KCC8SH6N
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM126982
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : Wellcome Trust
ID : 097753
Pays : United Kingdom
Informations de copyright
© 2022, Narasimhan et al.
Déclaration de conflit d'intérêts
JN, SL, SJ, AG, JW, MA, GC, JH, MD, GK, AB was employed by PTC Therapeutics when the work was performed and received salary and compensation during their tenure, KR, TL, CC, CD, JS No competing interests declared
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