Analysis of gingival crevicular fluid biomarkers in patients with metabolic syndrome.
biomarker
gingival crevicular fluid
metabolic syndrome
periodontitis
Journal
Journal of dentistry
ISSN: 1879-176X
Titre abrégé: J Dent
Pays: England
ID NLM: 0354422
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
received:
31
12
2021
revised:
01
02
2022
accepted:
05
02
2022
pubmed:
10
2
2022
medline:
7
4
2022
entrez:
9
2
2022
Statut:
ppublish
Résumé
To assess associations between gingival crevicular fluid (GCF) markers in patients with metabolic syndrome, with or without concomitant periodontitis. A total of 95 patients with Metabolic Syndrome (MetS) had a periodontal examination and gingival crevicular fluid samples taken. Proteomic analysis of gingival crevicular fluid (GCF) was carried out by Human XL Cytokine protein arrays in 12 selected patients, followed by multiplex ELISA of 11 analytes in 95 participants. Increased levels of Aggrecan, IL-6 and IL-8 were found in patients with periodontal health compared with moderate and severe periodontitis. The inverse stepwise association between severity of periodontitis and reduced Aggrecan levels was also observed at adjusted linear regression analysis. Diagnosis of diabetes was associated with higher GCF levels of IL-8 and MMP-8. Diabetes may affect GCF levels of cytokines, irrespective of periodontal status. Periodontal status may be associated with Aggrecan levels in the GCF of patients affected by metabolic syndrome. Investigation of GCF biomarkers may potentially help have diagnostic potential in patients with MetS.
Identifiants
pubmed: 35139411
pii: S0300-5712(22)00122-1
doi: 10.1016/j.jdent.2022.104065
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104065Informations de copyright
Copyright © 2022. Published by Elsevier Ltd.