Extravesicular TIMP-1 is a non-invasive independent prognostic marker and potential therapeutic target in colorectal liver metastases.

Colorectal Neoplasms / pathology Extracellular Vesicles / metabolism Humans Liver Neoplasms / metabolism Prognosis Tissue Inhibitor of Metalloproteinase-1 / metabolism Tumor Microenvironment

Journal

Oncogene
ISSN: 1476-5594
Titre abrégé: Oncogene
Pays: England
ID NLM: 8711562

Informations de publication

Date de publication:
03 2022
Historique:
received: 03 11 2021
accepted: 27 01 2022
revised: 08 01 2022
pubmed: 11 2 2022
medline: 20 4 2022
entrez: 10 2 2022
Statut: ppublish

Résumé

Molecular reprogramming of stromal microarchitecture by tumour-derived extracellular vesicles (EVs) is proposed to favour pre-metastatic niche formation. We elucidated the role of extravesicular tissue inhibitor of matrix metalloproteinase-1 (TIMP1

Identifiants

DOI: 10.1038/s41388-022-02218-9 PMID: 35140332 PMC: PMC8933275
pubmed: 35140332
doi: 10.1038/s41388-022-02218-9
pii: 10.1038/s41388-022-02218-9
pmc: PMC8933275
doi:

Substances chimiques

TIMP1 protein, human 0
Tissue Inhibitor of Metalloproteinase-1 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1809-1820

Informations de copyright

© 2022. The Author(s).

Références

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Auteurs

Venkatesh Sadananda Rao (VS)

Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
ORCID: 0000-0003-3647-2387

Qianyu Gu (Q)

Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Sandra Tzschentke (S)

Department of Medicine, Haematology/Oncology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.

Kuailu Lin (K)

Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Nicole Ganig (N)

Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

May-Linn Thepkaysone (ML)

Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Fang Cheng Wong (FC)

Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Heike Polster (H)

Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Lena Seifert (L)

Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
German Cancer Consortium (DKTK), German Cancer Research Centre (DKFZ), Heidelberg, Germany.
National Center for Tumor Diseases, Partner site Dresden, Heidelberg, Germany.

Adrian M Seifert (AM)

Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
German Cancer Consortium (DKTK), German Cancer Research Centre (DKFZ), Heidelberg, Germany.
National Center for Tumor Diseases, Partner site Dresden, Heidelberg, Germany.
ORCID: 0000-0002-5329-3164

Nathalie Buck (N)

Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Carina Riediger (C)

Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Jonas Weiße (J)

Junior Research Group 'RNA Biology and Pathogenesis', Medical Faculty, Martin-Luther University Halle-Wittenberg, Halle/Saale, Germany.

Tony Gutschner (T)

Junior Research Group 'RNA Biology and Pathogenesis', Medical Faculty, Martin-Luther University Halle-Wittenberg, Halle/Saale, Germany.
ORCID: 0000-0002-1722-3134

Susanne Michen (S)

Department of Neurosurgery, Section of Experimental Neurosurgery and Tumour Immunology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
ORCID: 0000-0002-5726-386X

Achim Temme (A)

Department of Neurosurgery, Section of Experimental Neurosurgery and Tumour Immunology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Martin Schneider (M)

Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany.

Franziska Baenke (F)

Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Jürgen Weitz (J)

Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
German Cancer Consortium (DKTK), German Cancer Research Centre (DKFZ), Heidelberg, Germany.
National Center for Tumor Diseases, Partner site Dresden, Heidelberg, Germany.

Christoph Kahlert (C)

Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. Christoph.Kahlert@uniklinikum-dresden.de.
German Cancer Consortium (DKTK), German Cancer Research Centre (DKFZ), Heidelberg, Germany. Christoph.Kahlert@uniklinikum-dresden.de.
National Center for Tumor Diseases, Partner site Dresden, Heidelberg, Germany. Christoph.Kahlert@uniklinikum-dresden.de.
ORCID: 0000-0003-4124-7918

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Classifications MeSH

questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › Extravesicular TIMP-1 is a non-invasive...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Vésicules extracellulaires › Extravesicular TIMP-1 is a non-invasive...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Extravesicular TIMP-1 is a non-invasive...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › Extravesicular TIMP-1 is a non-invasive...
questionsmedicales.fr › Diagnostic › Pronostic › Extravesicular TIMP-1 is a non-invasive...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines sécrétoires inhibitrices de protéinases › Inhibiteur tissulaire des métalloprotéinases › Inhibiteur tissulaire de métalloprotéinase-1 › Extravesicular TIMP-1 is a non-invasive...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Extravesicular TIMP-1 is a non-invasive...