Signatures of TOP1 transcription-associated mutagenesis in cancer and germline.
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
03
08
2021
accepted:
04
01
2022
pubmed:
11
2
2022
medline:
16
4
2022
entrez:
10
2
2022
Statut:
ppublish
Résumé
The mutational landscape is shaped by many processes. Genic regions are vulnerable to mutation but are preferentially protected by transcription-coupled repair
Identifiants
pubmed: 35140396
doi: 10.1038/s41586-022-04403-y
pii: 10.1038/s41586-022-04403-y
pmc: PMC8866115
doi:
Substances chimiques
Ribonucleotides
0
DNA Topoisomerases, Type I
EC 5.99.1.2
TOP1 protein, human
EC 5.99.1.2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
623-631Subventions
Organisme : Wellcome Trust
ID : 204802/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00007/5
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Blood Cancer UK
ID : 15047
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_14089
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K001744/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_EX_MR/M009203/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00007/11
Pays : United Kingdom
Investigateurs
John C Ambrose
(JC)
Prabhu Arumugam
(P)
Roel Bevers
(R)
Marta Bleda
(M)
Freya Boardman-Pretty
(F)
Christopher R Boustred
(CR)
Helen Brittain
(H)
Mark J Caulfield
(MJ)
Georgia C Chan
(GC)
Greg Elgar
(G)
Tom Fowler
(T)
Adam Giess
(A)
Angela Hamblin
(A)
Shirley Henderson
(S)
Tim J P Hubbard
(TJP)
Rob Jackson
(R)
Louise J Jones
(LJ)
Dalia Kasperaviciute
(D)
Melis Kayikci
(M)
Athanasios Kousathanas
(A)
Lea Lahnstein
(L)
Sarah E A Leigh
(SEA)
Ivonne U S Leong
(IUS)
Javier F Lopez
(JF)
Fiona Maleady-Crowe
(F)
Meriel McEntagart
(M)
Federico Minneci
(F)
Loukas Moutsianas
(L)
Michael Mueller
(M)
Nirupa Murugaesu
(N)
Anna C Need
(AC)
Peter O'Donovan
(P)
Chris A Odhams
(CA)
Christine Patch
(C)
Mariana Buongermino Pereira
(MB)
Daniel Perez-Gil
(D)
John Pullinger
(J)
Tahrima Rahim
(T)
Augusto Rendon
(A)
Tim Rogers
(T)
Kevin Savage
(K)
Kushmita Sawant
(K)
Richard H Scott
(RH)
Afshan Siddiq
(A)
Alexander Sieghart
(A)
Samuel C Smith
(SC)
Alona Sosinsky
(A)
Alexander Stuckey
(A)
Mélanie Tanguy
(M)
Ana Lisa Taylor Tavares
(AL)
Ellen R A Thomas
(ERA)
Simon R Thompson
(SR)
Arianna Tucci
(A)
Matthew J Welland
(MJ)
Eleanor Williams
(E)
Katarzyna Witkowska
(K)
Suzanne M Wood
(SM)
Daniel Chubb
(D)
Alex Cornish
(A)
Ben Kinnersley
(B)
Richard Houlston
(R)
David Wedge
(D)
Andreas Gruber
(A)
Anna Frangou
(A)
William Cross
(W)
Trevor Graham
(T)
Andrea Sottoriva
(A)
Gulio Caravagna
(G)
Nuria Lopez-Bigas
(N)
Claudia Arnedo-Pac
(C)
David Church
(D)
Richard Culliford
(R)
Steve Thorn
(S)
Phil Quirke
(P)
Henry Wood
(H)
Ian Tomlinson
(I)
Boris Noyvert
(B)
Commentaires et corrections
Type : CommentIn
Type : ErratumIn
Informations de copyright
© 2022. The Author(s).
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