Air quality improvement and incident dementia: Effects of observed and hypothetical reductions in air pollutant using parametric g-computation.


Journal

Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978

Informations de publication

Date de publication:
12 2022
Historique:
revised: 23 11 2021
received: 28 07 2021
accepted: 03 01 2022
pubmed: 11 2 2022
medline: 3 1 2023
entrez: 10 2 2022
Statut: ppublish

Résumé

No evidence exists about the impact of air pollution reduction on incidence of dementia. The aim of this study was to quantify how air quality improvement leads to dementia-incidence benefits. In the French Three-City cohort (12 years of follow-up), we used parametric g-computation to quantify the expected number of prevented dementia cases under different hypothetical interventions with particulate matter measuring <2.5 μm (PM Among 7051 participants, 789 participants developed dementia. The median PM These findings highlight the possible substantial benefits of reducing air pollution in the prevention of dementia.

Identifiants

pubmed: 35142029
doi: 10.1002/alz.12606
doi:

Substances chimiques

Air Pollutants 0
Particulate Matter 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2509-2517

Subventions

Organisme : NCI NIH HHS
ID : R01 CA228147
Pays : United States

Informations de copyright

© 2022 the Alzheimer's Association.

Références

Cohen AJ, Brauer M, Burnett R, et al. Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the global burden of diseases study 2015. Lancet. 2017;389(10082):1907-1918.
Burnett R, Chen H, Szyszkowicz M, et al. Global estimates of mortality associated with long-term exposure to outdoor fine particulate matter. Proc Natl Acad Sci U S A. 2018;115(38):9592-9597.
Bowe B, Xie Y, Yan Y, Al-Aly Z. Burden of cause-specific mortality associated with PM2.5 air pollution in the United States. JAMA Netw Open. 2019;2(11):e1915834.
Health Effects Institute. State of Global Air 2019. Health Effects Institut; 2019.
Block ML, Calderón-Garcidueñas L. Air pollution: mechanisms of neuroinflammation and CNS disease. Trends Neurosci. 2009;32(9):506-516.
de Prado Bert P, Mercader EMH, Pujol J, Sunyer J, Mortamais M. The effects of air pollution on the brain: a review of studies interfacing environmental epidemiology and neuroimaging. Curr Environ Health Rep. 2018;5(3):351-364.
Cho J, Noh Y, KimSun Y, et al. Long-Term ambient air pollution exposures and brain imaging markers in Korean Adults: the environmental pollution-induced neurological EFfects (EPINEF) Study. Environ Health Perspect. 2020;128(11):117006.
Chen H, Kwong JC, Copes R, et al. Exposure to ambient air pollution and the incidence of dementia: a population-based cohort study. Environ Int. 2017;108:271-277.
Power MC, Adar SD, Yanosky JD, Weuve J. Exposure to air pollution as a potential contributor to cognitive function, cognitive decline, brain imaging, and dementia: a systematic review of epidemiologic research. Neurotoxicology. 2016;56:235-253.
Peters R, Ee N, Peters J, Booth A, Mudway I, Anstey KJ. Air pollution and dementia: a systematic review. J Alzheimers Dis;70(1):S145-S163.
Shi L, Wu X, Yazdi MD, Braun D, Awad YA, Wei Y, et al. Long-term effects of PM2·5 on neurological disorders in the American Medicare population: a longitudinal cohort study. Lancet Planet Health. 2020;20:30227-30228.
Weuve J, Bennett EE, Ranker L, et al. Exposure to air pollution in relation to risk of dementia and related outcomes: an updated systematic review of the epidemiological literature. Environ Health Perspect. 2021;129(9):096001.
Mortamais M, Gutierrez L-A, de Hoogh K, et al. Long-term exposure to ambient air pollution and risk of dementia: results of the prospective Three-City Study. Environ Int. 2021;148:106376.
Livingston G, Huntley J, Sommerlad A, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. The Lancet. 2020;396(10248):413-446.
Amieva H, Le Goff M, Millet X, et al. Prodromal Alzheimer's disease: successive emergence of the clinical symptoms. Ann Neurol. 2008;64(5):492-498.
Breskin A, Edmonds A, Cole SR, et al. G-computation for policy-relevant effects of interventions on time-to-event outcomes. Int J Epidemiol. 2020;49(6):2021-2029.
Snowden JM, Rose S, Mortimer KM. Implementation of G-computation on a simulated data set: demonstration of a causal inference technique. Am J Epidemiol. 2011;173(7):731-738.
Keil AP, Edwards JK, Richardson DB, Naimi AI, Cole SR. The parametric g-formula for time-to-event data: intuition and a worked example. Epidemiol Camb Mass. 2014;25(6):889-897.
Taubman SL, Robins JM, Mittleman MA, Hernán MA. Intervening on risk factors for coronary heart disease: an application of the parametric g-formula. Int J Epidemiol. 2009;38(6):1599-1611.
Edwards JK, McGrath LJ, Buckley JP, Schubauer-Berigan MK, Cole SR, Richardson DB. Occupational radon exposure and lung cancer mortality: estimating intervention effects using the parametric g-formula. Epidemiol Camb Mass. 2014;25(6):829-834.
Mokhayeri Y, Hashemi-Nazari SS, Khodakarim S, et al. Effects of hypothetical interventions on ischemic stroke using parametric G-Formula. Stroke. 2019;50(11):3286-3288.
Rojas-Saunero LP, Hilal S, Murray EJ, Logan RW, Ikram MA, Swanson SA. Hypothetical blood-pressure-lowering interventions and risk of stroke and dementia. Eur J Epidemiol. 2021;36(1):69-79.
Zhou Z, Cai L, Fu J, Han Y, Fang Y. Hypothetical interventions on risk factors for cognitive impairment among Chinese older adults: an application of the parametric G-Formula. Int J Environ Res Public Health. 2020;17(3):1021.
Winblad B, Amouyel P, Andrieu S, et al. Defeating Alzheimer's disease and other dementias: a priority for European science and society. Lancet Neurol. 2016;15(5):455-532.
3C Study Group. Vascular factors and risk of dementia: design of the Three-City Study and baseline characteristics of the study population. Neuroepidemiology. 2003;22(6):316-325.
de Hoogh K, Chen J, Gulliver J, et al. Spatial PM2.5, NO2, O3 and BC models for Western Europe - Evaluation of spatiotemporal stability. Environ Int. 2018;120:81-92.
Brandt J, Silver JD, Frohn LM, et al. An integrated model study for Europe and North America using the Danish Eulerian Hemispheric Model with focus on intercontinental transport of air pollution. Atmos Environ. 2012;53:156-176.
McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34(7):939-944.
Lange T, Hansen JV. Direct and indirect effects in a survival context. Epidemiol Camb Mass. 2011;22(4):575-581.
Aalen O, A model for nonparametric regression analysis of counting processes. In: Klonecki W, Kozek A, Rosiński J, eds. A Model for Nonparametric Regression Analysis of Counting Processes. Mathematical Statistics and Probability Theory. Springer; 1980:1-25.
Letellier N, Gutierrez L-A, Carrière I, et al. Sex-specific association between neighborhood characteristics and dementia: the Three-City cohort. Alzheimers Dement. 2018;14(4):473-482.
Zureik M, Gariépy J, Courbon D, et al. Alcohol consumption and carotid artery structure in older French adults: the Three-City Study. Stroke. 2004;35(12):2770-2775.
Hernán MA, Robins JM. Causal Inference: What If. Chapman & Hall/CRC; 2020.
Naimi AI, Cole SR, Kennedy EH. An introduction to g methods. Int J Epidemiol. 2017;46(2):756-762.
Hernán MA. The hazards of hazard ratios. Epidemiol Camb Mass janv. 2010;21(1):13-15.
McGrath S, Lin V, Zhang Z, et al. gfoRmula: an R package for estimating the effects of sustained treatment strategies via the Parametric g-formula. Patterns N Y N. 2020;1(3):100008.
Oakes JM, Kaufman JS. Methods in Social Epidemiology. 2017.
Ilango SD, Chen H, Hystad P, et al. The role of cardiovascular disease in the relationship between air pollution and incident dementia: a population-based cohort study. Int J Epidemiol. 2020;49(1):36-44.
Grande G, Ljungman PLS, Eneroth K, Bellander T, Rizzuto D. Association between cardiovascular disease and long-term exposure to air pollution with the risk of dementia. JAMA Neurol. 2020;77(7):801-809.
Chen H, Kwong JC, Copes R, et al. Living near major roads and the incidence of dementia, Parkinson's disease, and multiple sclerosis: a population-based cohort study. Lancet. 2017;389(10070):718-726.
Oudin A, Forsberg B, AdolfssonAnnelie N, et al. Traffic-Related air pollution and dementia incidence in Northern Sweden: a longitudinal study. Environ Health Perspect. 2016;124(3):306-312.
Jung C-R, Lin Y-T, Hwang B-F. Ozone, particulate matter, and newly diagnosed Alzheimer's disease: a population-based cohort study in Taiwan. J Alzheimers Dis JAD. 2015;44(2):573-584.
Chang K-H, Chang M-Y, Muo C-H, Wu T-N, Chen C-Y, Kao C-H. Increased risk of dementia in patients exposed to nitrogen dioxide and carbon monoxide: a population-based retrospective cohort study. PloS One. 2014;9(8):e103078.
Carey IM, Anderson HR, Atkinson RW, et al. Are noise and air pollution related to the incidence of dementia? A cohort study in London, England. BMJ Open. 2018;8(9):e022404.
Nunez Y, Boehme Amelia K, Weisskopf Marc G, et al. Fine particle exposure and clinical aggravation in neurodegenerative diseases in New York State. Environ Health Perspect. 2021;129(2):027003.
Calderón-Garcidueñas L, Villarreal-Ríos R. Living close to heavy traffic roads, air pollution, and dementia. Lancet. 2017;389(10070):675-677.
Hernán MA, Robins JM. Using big data to emulate a target trial when a randomized trial is not available. Am J Epidemiol. 2016;183(8):758-764.
Oulhote Y, Coull B, Bind M-A, et al. Joint and independent neurotoxic effects of early life exposures to a chemical mixture: a multi-pollutant approach combining ensemble learning and G-computation. Environ Epidemiol. 2019;3(5):e063.
Garcia E, Berhane KT, Islam T, et al. Association of changes in air quality with incident asthma in children in California, 1993-2014. JAMA. 2019;321(19):1906-1915.
Urman R, Garcia E, Berhane K, McConnell R, Gauderman WJ, Gilliland F. The potential effects of policy-driven air pollution interventions on childhood lung development. Am J Respir Crit Care Med. 2019;201(4):438-444.
Jayaraj RL, Rodriguez EA, Wang Y, Block ML. Outdoor ambient air pollution and neurodegenerative diseases: the neuroinflammation hypothesis. Curr Environ Health Rep. 2017;4(2):166-179.
Kilian J, Kitazawa M. The emerging risk of exposure to air pollution on cognitive decline and Alzheimer's disease - Evidence from epidemiological and animal studies. Biomed J. 2018;41(3):141-162.
Calderón-Garcidueñas L, Solt AC, Henríquez-Roldán C, et al. Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid β-42 and α-Synuclein in children and young adults. Toxicol Pathol. 2008;36(2):289-310.
Calderón-Garcidueñas L, González-Maciel A, Reynoso-et al. Quadruple abnormal protein aggregates in brainstem pathology and exogenous metal-rich magnetic nanoparticles (and engineered Ti-rich nanorods). The substantia nigrae is a very early target in young urbanites and the gastrointestinal tract a key brainstem portal. Environ Res. 2020;191:110139.
Cserbik D, Chen J-C, McConnell R, et al. Fine particulate matter exposure during childhood relates to hemispheric-specific differences in brain structure. Environ Int. 2020;143:105933.
Beckwith T, Cecil K, Altaye M, et al. Reduced gray matter volume and cortical thickness associated with traffic-related air pollution in a longitudinally studied pediatric cohort. PLOS ONE. 2020;15(1):e0228092.

Auteurs

Noémie Letellier (N)

Herbert Wertheim School of Public Health and Human Longevity Science & Scripps Institution of Oceanography, UC San Diego, San Diego, California, USA.

Laure-Anne Gutierrez (LA)

Institute for Neurosciences of Montpellier INM, Univ Montpellier, INSERM, Montpellier, France.

Jeanne Duchesne (J)

Institute for Neurosciences of Montpellier INM, Univ Montpellier, INSERM, Montpellier, France.

Chen Chen (C)

Herbert Wertheim School of Public Health and Human Longevity Science & Scripps Institution of Oceanography, UC San Diego, San Diego, California, USA.

Sindana Ilango (S)

Department of Epidemiology, University of Washington School of Public Health, Seattle, USA.

Catherine Helmer (C)

Bordeaux Population Health Research Center, Université de Bordeaux, INSERM, UMR 1219, Bordeaux, France.

Claudine Berr (C)

Institute for Neurosciences of Montpellier INM, Univ Montpellier, INSERM, Montpellier, France.
Memory Research and Resources Center, Department of Neurology, Montpellier University Hospital Gui de Chauliac, Montpellier, France.

Marion Mortamais (M)

Institute for Neurosciences of Montpellier INM, Univ Montpellier, INSERM, Montpellier, France.

Tarik Benmarhnia (T)

Herbert Wertheim School of Public Health and Human Longevity Science & Scripps Institution of Oceanography, UC San Diego, San Diego, California, USA.

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