A vibrissa pathway that activates the limbic system.
kolliker fuse
mouse
neuroscience
paralemniscal
rat
trigeminus
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
10 02 2022
10 02 2022
Historique:
received:
10
07
2021
accepted:
24
01
2022
entrez:
10
2
2022
pubmed:
11
2
2022
medline:
4
3
2022
Statut:
epublish
Résumé
Vibrissa sensory inputs play a central role in driving rodent behavior. These inputs transit through the sensory trigeminal nuclei, which give rise to the ascending lemniscal and paralemniscal pathways. While lemniscal projections are somatotopically mapped from brainstem to cortex, those of the paralemniscal pathway are more widely distributed. Yet the extent and topography of paralemniscal projections are unknown, along with the potential role of these projections in controlling behavior. Here, we used viral tracers to map paralemniscal projections. We find that this pathway broadcasts vibrissa-based sensory signals to brainstem regions that are involved in the regulation of autonomic functions and to forebrain regions that are involved in the expression of emotional reactions. We further provide evidence that GABAergic cells of the Kölliker-Fuse nucleus gate trigeminal sensory input in the paralemniscal pathway via a mechanism of presynaptic or extrasynaptic inhibition.
Identifiants
pubmed: 35142608
doi: 10.7554/eLife.72096
pii: 72096
pmc: PMC8830883
doi:
pii:
Banques de données
Dryad
['10.5061/dryad.D15C7X']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NINDS NIH HHS
ID : R35 NS097265
Pays : United States
Organisme : NINDS NIH HHS
ID : U19 NS107466
Pays : United States
Organisme : CIHR
ID : MT-5877
Pays : Canada
Informations de copyright
© 2022, Elbaz et al.
Déclaration de conflit d'intérêts
ME, AC, MD, SZ, CF, DK, MD No competing interests declared
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