Clinical patterns of somatic symptoms in patients suffering from post-acute long COVID: a systematic review.
COVID-19
Long COVID
Long-term persistence
Sequelae symptoms
Journal
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
ISSN: 1435-4373
Titre abrégé: Eur J Clin Microbiol Infect Dis
Pays: Germany
ID NLM: 8804297
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
09
07
2021
accepted:
31
01
2022
pubmed:
11
2
2022
medline:
23
3
2022
entrez:
10
2
2022
Statut:
ppublish
Résumé
Long COVID-19 may affect patients after hospital discharge. This study aims to describe the burden of the long-term persistence of clinical symptoms in COVID-19 patients. We conducted a systematic review by using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guideline. The PubMed and Google Scholar databases were searched for studies that included information on the prevalence of somatic clinical symptoms lasting at least 4 weeks after the onset of a PCR- or serology-confirmed diagnosis of COVID-19. The prevalence of persisting clinical symptoms was assessed and risk factors were described when investigated. Psychological symptoms and cognitive disorders were not evaluated in this study. Thirty-seven articles met the inclusion criteria. Eighteen studies involved in-patients only with a duration of follow-up of either less than 12 weeks, 12 weeks to 6 months, or more. In these studies, fatigue (16-64%), dyspnea (15-61%), cough (2-59%), arthralgia (8-55%), and thoracic pain (5-62%) were the most frequent persisting symptoms. In nineteen studies conducted in a majority of out-patients, the persistence of these symptoms was lower and 3% to 74% of patients reported prolonged smell and taste disorders. The main risk factors for persisting symptoms were being female, older, having comorbidities and severity at the acute phase of the disease. COVID-19 patients should have access to dedicated multidisciplinary healthcare allowing a holistic approach. Effective outpatient care for patients with long-COVID-19 requires coordination across multiple sub-specialties, which can be proposed in specialized post-COVID units.
Sections du résumé
BACKGROUND
BACKGROUND
Long COVID-19 may affect patients after hospital discharge.
AIMS
OBJECTIVE
This study aims to describe the burden of the long-term persistence of clinical symptoms in COVID-19 patients.
METHODS
METHODS
We conducted a systematic review by using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guideline. The PubMed and Google Scholar databases were searched for studies that included information on the prevalence of somatic clinical symptoms lasting at least 4 weeks after the onset of a PCR- or serology-confirmed diagnosis of COVID-19. The prevalence of persisting clinical symptoms was assessed and risk factors were described when investigated. Psychological symptoms and cognitive disorders were not evaluated in this study.
RESULTS
RESULTS
Thirty-seven articles met the inclusion criteria. Eighteen studies involved in-patients only with a duration of follow-up of either less than 12 weeks, 12 weeks to 6 months, or more. In these studies, fatigue (16-64%), dyspnea (15-61%), cough (2-59%), arthralgia (8-55%), and thoracic pain (5-62%) were the most frequent persisting symptoms. In nineteen studies conducted in a majority of out-patients, the persistence of these symptoms was lower and 3% to 74% of patients reported prolonged smell and taste disorders. The main risk factors for persisting symptoms were being female, older, having comorbidities and severity at the acute phase of the disease.
CONCLUSION
CONCLUSIONS
COVID-19 patients should have access to dedicated multidisciplinary healthcare allowing a holistic approach. Effective outpatient care for patients with long-COVID-19 requires coordination across multiple sub-specialties, which can be proposed in specialized post-COVID units.
Identifiants
pubmed: 35142947
doi: 10.1007/s10096-022-04417-4
pii: 10.1007/s10096-022-04417-4
pmc: PMC8830952
doi:
Types de publication
Journal Article
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
515-545Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Clin Infect Dis. 2022 Apr 9;74(7):1191-1198
pubmed: 34223884
Thorax. 2021 Apr;76(4):405-407
pubmed: 33273028
Open Forum Infect Dis. 2020 Sep 12;7(10):ofaa420
pubmed: 33117851
J Intern Med. 2019 Apr;285(4):352-366
pubmed: 30372565
Ann Intern Med. 2021 Apr;174(4):576-578
pubmed: 33175566
J Am Med Dir Assoc. 2021 Sep;22(9):1840-1844
pubmed: 34352201
Clin Infect Dis. 2021 Aug 2;73(3):e826-e829
pubmed: 33624010
Acta Paediatr. 2021 Jul;110(7):2208-2211
pubmed: 33835507
Ann Intern Med. 2021 May;174(5):723-725
pubmed: 33284676
Nat Med. 2021 Apr;27(4):601-615
pubmed: 33753937
Eur Respir J. 2021 Apr 29;57(4):
pubmed: 33303539
Curr Trop Med Rep. 2020;7(3):75-78
pubmed: 32313804
J Med Virol. 2021 Feb;93(2):1013-1022
pubmed: 32729939
Chest. 2021 Aug;160(2):671-677
pubmed: 33811910
J Med Virol. 2021 Dec;93(12):6566-6574
pubmed: 34255355
Hum Antibodies. 2021;29(2):139-148
pubmed: 32804122
Nat Med. 2021 Sep;27(9):1607-1613
pubmed: 34163090
Viruses. 2021 Apr 18;13(4):
pubmed: 33919537
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
Travel Med Infect Dis. 2021 Mar-Apr;40:101995
pubmed: 33631340
Ann Clin Transl Neurol. 2021 May;8(5):1073-1085
pubmed: 33755344
Int Forum Allergy Rhinol. 2021 Dec;11(12):1685-1688
pubmed: 34109765
Curr Atheroscler Rep. 2021 May 13;23(7):37
pubmed: 33983522
Clin Microbiol Infect. 2021 Feb;27(2):258-263
pubmed: 33031948
Clin Microbiol Infect. 2021 Jul;27(7):1041.e1-1041.e4
pubmed: 34125067
Eur J Phys Rehabil Med. 2021 Apr;57(2):199-207
pubmed: 33565741
Lancet. 2021 Jan 16;397(10270):220-232
pubmed: 33428867
PLoS One. 2020 Dec 11;15(12):e0243882
pubmed: 33306721
EClinicalMedicine. 2020 Aug;25:100463
pubmed: 32838236
JAMA. 2020 Aug 11;324(6):603-605
pubmed: 32644129
Infect Dis (Lond). 2021 Oct;53(10):737-754
pubmed: 34024217
Open Forum Infect Dis. 2020 Oct 21;7(12):ofaa509
pubmed: 33403218
J Neurovirol. 2021 Feb;27(1):154-159
pubmed: 33528827
Clin Microbiol Infect. 2021 Jun;27(6):931-932
pubmed: 33418020
Respir Med. 2020 Nov - Dec;174:106197
pubmed: 33120193
Healthcare (Basel). 2020 Dec 11;8(4):
pubmed: 33322316
J Infect. 2020 Dec;81(6):e4-e6
pubmed: 32853602
Biology (Basel). 2021 May 26;10(6):
pubmed: 34073342
Lancet. 2003 Oct 25;362(9393):1353-8
pubmed: 14585636
JAMA Netw Open. 2021 Jul 1;4(7):e2118717
pubmed: 34323987
Clin Microbiol Infect. 2021 Jan;27(1):89-95
pubmed: 32979574
Eur J Nucl Med Mol Imaging. 2021 Aug;48(9):2823-2833
pubmed: 33501506
Med Clin (Engl Ed). 2021 Jan 10;156(1):35-36
pubmed: 33521308
Lancet Gastroenterol Hepatol. 2021 May;6(5):344-346
pubmed: 33711290
Sci Rep. 2021 Jun 23;11(1):13153
pubmed: 34162913
Free Neuropathol. 2021 Jan 18;2:
pubmed: 33554218
Clin Infect Dis. 2021 Dec 6;73(11):e4058-e4063
pubmed: 33252665
Iran J Med Sci. 2021 Nov;46(6):428-436
pubmed: 34840383
J Korean Med Sci. 2020 Dec 07;35(47):e418
pubmed: 33289374
Infection. 2021 Oct;49(5):1007-1015
pubmed: 34091869
Respiration. 2022;101(2):132-141
pubmed: 34569550
JACC Case Rep. 2021 Apr;3(4):573-580
pubmed: 33723532
Clin Med (Lond). 2021 Jan;21(1):e63-e67
pubmed: 33243837
Expert Rev Clin Immunol. 2020 Dec;16(12):1159-1184
pubmed: 33356661
Acta Anaesthesiol Scand. 2021 Aug;65(7):912-920
pubmed: 33655487