Transcriptome signature changes in the liver of a migratory passerine.
Animal model
Cell cycle
Circadian cycle
Liver
Long-distance avian migration
Obesity-related diseases
PPARs
Polyploidization and increased metabolic capacity
RNA-Seq
Journal
Genomics
ISSN: 1089-8646
Titre abrégé: Genomics
Pays: United States
ID NLM: 8800135
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
received:
05
04
2021
revised:
13
12
2021
accepted:
31
01
2022
pubmed:
11
2
2022
medline:
26
4
2022
entrez:
10
2
2022
Statut:
ppublish
Résumé
The liver plays a principal role in avian migration. Here, we characterised the liver transcriptome of a long-distance migrant, the Northern Wheatear (Oenanthe oenanthe), sampled at different migratory stages, looking for molecular processes linked with adaptations to migration. The analysis of the differentially expressed genes suggested changes in the periods of the circadian rhythm, variation in the proportion of cells in G1/S cell-cycle stages and the putative polyploidization of this cell population. This may explain the dramatic increment in the liver's metabolic capacities towards migration. Additionally, genes involved in anti-oxidative stress, detoxification and innate immune responses, lipid metabolism, inflammation and angiogenesis were regulated. Lipophagy and lipid catabolism were active at all migratory stages and increased towards the fattening and fat periods, explaining the relevance of lipolysis in controlling steatosis and maintaining liver health. Our study clears the way for future functional studies regarding long-distance avian migration.
Identifiants
pubmed: 35143886
pii: S0888-7543(22)00028-3
doi: 10.1016/j.ygeno.2022.110283
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
110283Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.