Distinct structural bases for sequence-specific DNA binding by mammalian BEN domain proteins.

Animals Binding Sites Drosophila / metabolism Mammals Protein Binding Protein Domains Repressor Proteins / genetics Transcription Factors / metabolism
DNA binding activity gene regulation protein–DNA structure transcription factor

Journal

Genes & development
ISSN: 1549-5477
Titre abrégé: Genes Dev
Pays: United States
ID NLM: 8711660

Informations de publication

Date de publication:
01 02 2022
Historique:
received: 02 09 2021
accepted: 05 01 2022
pubmed: 12 2 2022
medline: 3 5 2022
entrez: 11 2 2022
Statut: ppublish

Résumé

The BEN domain is a recently recognized DNA binding module that is present in diverse metazoans and certain viruses. Several BEN domain factors are known as transcriptional repressors, but, overall, relatively little is known of how BEN factors identify their targets in humans. In particular, X-ray structures of BEN domain:DNA complexes are only known for

Identifiants

DOI: 10.1101/gad.348993.121 PMID: 35144965 PMC: PMC8887127
pubmed: 35144965
pii: gad.348993.121
doi: 10.1101/gad.348993.121
pmc: PMC8887127
doi:

Substances chimiques

Repressor Proteins 0
Transcription Factors 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

225-240

Subventions

Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM125196
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS074037
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS083833
Pays : United States

Informations de copyright

© 2022 Zheng et al.; Published by Cold Spring Harbor Laboratory Press.

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Auteurs

Luqian Zheng (L)

The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, Guangdong 518033, China.
Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China.

Jingjing Liu (J)

State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China.

Lijie Niu (L)

State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China.

Mohammad Kamran (M)

Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.

Ally W H Yang (AWH)

Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A1, Canada.
Donnelly Centre, University of Toronto, Toronto, Ontario M5S 1A1, Canada.

Arttu Jolma (A)

Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A1, Canada.
Donnelly Centre, University of Toronto, Toronto, Ontario M5S 1A1, Canada.

Qi Dai (Q)

Developmental Biology Program, Sloan Kettering Institute, New York, New York 10065, USA.
ORCID: 0000-0002-2082-0693

Timothy R Hughes (TR)

Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A1, Canada.
Donnelly Centre, University of Toronto, Toronto, Ontario M5S 1A1, Canada.
ORCID: 0000-0002-8721-4719

Dinshaw J Patel (DJ)

Structural Biology Program, Sloan Kettering Institute, New York, New York 10065, USA.

Long Zhang (L)

The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, Guangdong 518033, China.
Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China.

Supriya G Prasanth (SG)

Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.

Yang Yu (Y)

State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China.
Developmental Biology Program, Sloan Kettering Institute, New York, New York 10065, USA.

Aiming Ren (A)

Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China.

Eric C Lai (EC)

Developmental Biology Program, Sloan Kettering Institute, New York, New York 10065, USA.
ORCID: 0000-0002-8432-5851

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Classifications MeSH

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