Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills.

Child Cognition CpG Islands / genetics DNA Methylation / genetics Epigenesis, Genetic / genetics Epigenome Female Genome-Wide Association Study Humans Infant, Newborn Pregnancy

Journal

Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835

Informations de publication

Date de publication:
04 2022
Historique:
received: 29 04 2021
accepted: 11 01 2022
pubmed: 12 2 2022
medline: 26 5 2022
entrez: 11 2 2022
Statut: ppublish

Résumé

Cognitive skills are a strong predictor of a wide range of later life outcomes. Genetic and epigenetic associations across the genome explain some of the variation in general cognitive abilities in the general population and it is plausible that epigenetic associations might arise from prenatal environmental exposures and/or genetic variation early in life. We investigated the association between cord blood DNA methylation at birth and cognitive skills assessed in children from eight pregnancy cohorts within the Pregnancy And Childhood Epigenetics (PACE) Consortium across overall (total N = 2196), verbal (total N = 2206) and non-verbal cognitive scores (total N = 3300). The associations at single CpG sites were weak for all of the cognitive domains investigated. One region near DUSP22 on chromosome 6 was associated with non-verbal cognition in a model adjusted for maternal IQ. We conclude that there is little evidence to support the idea that variation in cord blood DNA methylation at single CpG sites is associated with cognitive skills and further studies are needed to confirm the association at DUSP22.

Identifiants

DOI: 10.1038/s41380-022-01441-w PMID: 35145228 PMC: PMC9126809
pubmed: 35145228
doi: 10.1038/s41380-022-01441-w
pii: 10.1038/s41380-022-01441-w
pmc: PMC9126809
mid: EMS140785
doi:

Types de publication

Journal Article Meta-Analysis Research Support, Non-U.S. Gov't Research Support, N.I.H., Intramural Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

2126-2135

Subventions

Organisme : Medical Research Council
ID : MC_UU_00011/5
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00011/6
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 217065/Z/19/Z
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBI025751/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/I025263/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00011/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S009310/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S036520/1
Pays : United Kingdom
Organisme : NICHD NIH HHS
ID : R01 HD068437
Pays : United States
Organisme : CIHR
Pays : Canada
Organisme : NICHD NIH HHS
ID : R01 HD034568
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023286
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES031259
Pays : United States
Organisme : NIEHS NIH HHS
ID : P01 ES009605
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES021369
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES023067
Pays : United States
Organisme : NIEHS NIH HHS
ID : R24 ES028529
Pays : United States
Organisme : NIEHS NIH HHS
ID : F31 ES027751
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA035300
Pays : United States
Organisme : NIH HHS
ID : UG3 OD023356
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH112510
Pays : United States

Informations de copyright

© 2022. The Author(s).

Références

Mol Psychiatry. 2021 Jun;26(6):1832-1845
pubmed: 33414500
Psychol Sci. 2016 Feb;27(2):138-149
pubmed: 26671911
Nat Commun. 2016 Feb 10;7:10577
pubmed: 26861414
Am J Hum Genet. 2011 May 13;88(5):586-98
pubmed: 21565292
Mol Psychiatry. 2014 Apr;19(4):495-503
pubmed: 23608919
NPJ Schizophr. 2018 Aug 21;4(1):16
pubmed: 30131491
J Pediatr Oncol Nurs. 1996 Jan;13(1):3-12; discussion 13-4
pubmed: 8904461
Cancer Epidemiol Biomarkers Prev. 2014 Jun;23(6):1007-17
pubmed: 24740201
Int J Epidemiol. 2012 Aug;41(4):930-40
pubmed: 21471022
Annu Rev Psychol. 2012;63:453-82
pubmed: 21943169
Schizophr Bull. 2016 Mar;42(2):406-14
pubmed: 26056378
Am J Psychiatry. 2021 Jul;178(7):625-634
pubmed: 33900812
J Pediatr. 2007 Sep;151(3):284-8, 288.e1
pubmed: 17719939
Mol Psychiatry. 2015 Feb;20(1):98-108
pubmed: 25224258
Genome Med. 2018 Mar 28;10(1):19
pubmed: 29587883
JAMA Psychiatry. 2016 May 1;73(5):506-14
pubmed: 27074206
Transl Psychiatry. 2014 Aug 26;4:e429
pubmed: 25158004
Neurol Genet. 2019 Jun 24;5(4):e342
pubmed: 31403079
PLoS One. 2015 Sep 09;10(9):e0137219
pubmed: 26352937
Neuropsychol Rev. 2010 Dec;20(4):327-48
pubmed: 21042938
Bioinformatics. 2017 Apr 15;33(8):1243-1245
pubmed: 28119308
Int J Epidemiol. 2018 Feb 1;47(1):22-23u
pubmed: 29025028
J Epidemiol Community Health. 2003 Sep;57(9):681-6
pubmed: 12933773
Curr Behav Neurosci Rep. 2016 Sep;3(3):264-274
pubmed: 28093577
Int J Epidemiol. 2013 Feb;42(1):111-27
pubmed: 22507743
Prog Neurobiol. 2021 Mar;198:101906
pubmed: 32905807
Transl Psychiatry. 2020 Nov 12;10(1):398
pubmed: 33184255
Int J Epidemiol. 2015 Feb;44(1):37-48
pubmed: 24639442
Int J Epidemiol. 2013 Feb;42(1):97-110
pubmed: 22507742
Nat Genet. 2017 Jan;49(1):139-145
pubmed: 27918533
Nat Commun. 2019 Apr 23;10(1):1893
pubmed: 31015461
Nat Commun. 2016 Apr 07;7:11115
pubmed: 27051996
Epigenetics. 2016 May 3;11(5):354-62
pubmed: 27019159
Mol Psychiatry. 2018 Nov;23(11):2133-2144
pubmed: 29311653
Eur J Epidemiol. 2016 Dec;31(12):1243-1264
pubmed: 28070760
Transl Psychiatry. 2017 Aug 1;7(8):e1187
pubmed: 28763057
Epigenetics. 2015;10(11):1024-32
pubmed: 26457534
Mol Autism. 2019 Jul 17;10:31
pubmed: 31346403
Assessment. 2018 Sep;25(6):691-701
pubmed: 27497247
Dev Psychopathol. 2022 Aug;34(3):854-863
pubmed: 33494854
Hippocampus. 2014 Apr;24(4):363-8
pubmed: 24436131
J Learn Disabil. 2001 Jan-Feb;34(1):2-8
pubmed: 15497268
Am J Hum Genet. 2016 Apr 7;98(4):680-96
pubmed: 27040690
Mol Psychiatry. 2017 Dec;22(12):1680-1690
pubmed: 29086770
Environ Health Perspect. 2004 Jul;112(10):1116-24
pubmed: 15238287
Int J Epidemiol. 2017 Oct 1;46(5):1380-1381g
pubmed: 27639277
Int J Epidemiol. 2016 Apr;45(2):353-63
pubmed: 26283636
JAMA Pediatr. 2020 Nov 1;174(11):1063-1072
pubmed: 32955555
BMJ. 2003 Sep 6;327(7414):557-60
pubmed: 12958120

Auteurs

Doretta Caramaschi (D)

Medical Research Council Integrative Epidemiology Unit (MRC IEU), Bristol Medical School, Population Health Science, University of Bristol, Bristol, UK. d.caramaschi@exeter.ac.uk.
Department of Psychology, College of Life and Environmental Sciences, University of Exeter, Exeter, UK. d.caramaschi@exeter.ac.uk.
ORCID: 0000-0002-9740-871X

Alexander Neumann (A)

Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.

Andres Cardenas (A)

Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
ORCID: 0000-0003-2284-3298

Gwen Tindula (G)

Children's Environmental Health Laboratory, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.

Silvia Alemany (S)

ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
Universitat Pompeu Fabra (UPF), Barcelona, Spain.
CIBER Epidemiology and Public Health (CIBERESP), Madrid, Spain.

Lea Zillich (L)

Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.

Giancarlo Pesce (G)

Epidemiology of Allergic and Respiratory Diseases Team (EPAR), Institute Pierre Louis of Epidemiology and Public Health, UMR-S 1136 INSERM and Sorbonne Université, Paris, France.
ORCID: 0000-0003-4925-6325

Jari M T Lahti (JMT)

Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
ORCID: 0000-0002-4310-5297

Alexandra Havdahl (A)

Medical Research Council Integrative Epidemiology Unit (MRC IEU), Bristol Medical School, Population Health Science, University of Bristol, Bristol, UK.
Department of Mental Disorders, Norwegian Institute of Public Health and Nic Waals Institute of Lovisenberg Diaconal Hospital, Oslo, Norway.
ORCID: 0000-0002-9268-0423

Rosa Mulder (R)

Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Janine F Felix (JF)

The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
ORCID: 0000-0002-9801-5774

Henning Tiemeier (H)

Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
ORCID: 0000-0002-4395-1397

Lea Sirignano (L)

Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
ORCID: 0000-0002-7989-5833

Josef Frank (J)

Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
ORCID: 0000-0003-4867-9465

Stephanie H Witt (SH)

Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
ORCID: 0000-0002-1571-1468

Marcella Rietschel (M)

Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
ORCID: 0000-0002-5236-6149

Michael Deuschle (M)

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Karen Huen (K)

Children's Environmental Health Laboratory, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.

Brenda Eskenazi (B)

Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, CA, USA.

Tabea Sarah Send (TS)

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Muriel Ferrer (M)

ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.

Maria Gilles (M)

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Maria de Agostini (M)

Inserm, Centre for Research in Epidemiology and StatisticS (CRESS), Research Team on Early Life Origins of Health (EAROH), Villejuif, France.

Nour Baïz (N)

Epidemiology of Allergic and Respiratory Diseases Team (EPAR), Institute Pierre Louis of Epidemiology and Public Health, UMR-S 1136 INSERM and Sorbonne Université, Paris, France.

Sheryl L Rifas-Shiman (SL)

Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.

Tuomas Kvist (T)

Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Darina Czamara (D)

Department of Translational Research in Psychiatry, Max-Planck-Institute of Psychiatry, Munich, Germany.
ORCID: 0000-0001-7381-904X

Samuli T Tuominen (ST)

Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Caroline L Relton (CL)

Medical Research Council Integrative Epidemiology Unit (MRC IEU), Bristol Medical School, Population Health Science, University of Bristol, Bristol, UK.

Dheeraj Rai (D)

Medical Research Council Integrative Epidemiology Unit (MRC IEU), Bristol Medical School, Population Health Science, University of Bristol, Bristol, UK.

Stephanie J London (SJ)

National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.
ORCID: 0000-0003-4911-5290

Katri Räikkönen (K)

Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Nina Holland (N)

Children's Environmental Health Laboratory, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.

Isabella Annesi-Maesano (I)

Epidemiology of Allergic and Respiratory Diseases Team (EPAR), Institute Pierre Louis of Epidemiology and Public Health, UMR-S 1136 INSERM and Sorbonne Université, Paris, France.
ORCID: 0000-0002-6340-9300

Fabian Streit (F)

Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
ORCID: 0000-0003-1080-4339

Marie-France Hivert (MF)

Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.

Emily Oken (E)

Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.

Jordi Sunyer (J)

ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
Universitat Pompeu Fabra (UPF), Barcelona, Spain.
CIBER Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.

Charlotte A M Cecil (CAM)

Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.

Gemma Sharp (G)

Medical Research Council Integrative Epidemiology Unit (MRC IEU), Bristol Medical School, Population Health Science, University of Bristol, Bristol, UK.
ORCID: 0000-0003-2906-4035

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Meta-analysis of epigenome-wide associations...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Meta-analysis of epigenome-wide associations...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Ilots CpG › Meta-analysis of epigenome-wide associations...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Meta-analysis of epigenome-wide associations...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Meta-analysis of epigenome-wide associations...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Épigénome › Meta-analysis of epigenome-wide associations...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Meta-analysis of epigenome-wide associations...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Meta-analysis of epigenome-wide associations...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Meta-analysis of epigenome-wide associations...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Meta-analysis of epigenome-wide associations...